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SCH900776

Catalog No. T2517   CAS 891494-63-6
Synonyms: MK 8776, MK-8776

SCH900776 (MK-8776) is an agent targeting cell cycle checkpoint kinase 1 (Chk1) with potential radiosensitization and chemosensitization activities.

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SCH900776 Chemical Structure
SCH900776, CAS 891494-63-6
Pack Size Availability Price/USD Quantity
1 mg In stock $ 48.00
2 mg In stock $ 71.00
5 mg In stock $ 117.00
10 mg In stock $ 171.00
25 mg In stock $ 297.00
50 mg In stock $ 486.00
100 mg In stock $ 695.00
1 mL * 10 mM (in DMSO) In stock $ 126.00
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Purity: 99.6%
Purity: 99.45%
Purity: 98.35%
Purity: 98%
Purity: 96.69%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description SCH900776 (MK-8776) is an agent targeting cell cycle checkpoint kinase 1 (Chk1) with potential radiosensitization and chemosensitization activities.
Targets&IC50 Chk1:3 nM, CDK2:0.16 μM
Kinase Assay The Millipore Kinase Profiler service is used to generate general selectivity data for SCH 900776 against a broad range of serine/threonine and tyrosine kinases. Assays are typically run at two concentrations of SCH 900776 (0.5 and 5 μM), at a fixed (10 μM) concentration of ATP. Data are provided as percent activity remaining, relative to uninhibited controls.
Cell Research For cell growth assays, cells are seeded at low density (500-1000 cells) in 96-well plates and then incubated with drug for 24 h (8 wells per concentration). Following treatment, cells are washed and grown in fresh media for 5-7 days at 37°C. Prior to attaining confluence, cells are washed, lysed, and stained with Hoechst 33258. Fluorescence is read on a microplate spectrofluorometer. Results are expressed as mean and standard error for the concentration of drug that inhibited growth by 50%.
Synonyms MK 8776, MK-8776
Molecular Weight 376.25
Formula C15H18BrN7
CAS No. 891494-63-6

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 100 mg/mL (265.78 mM)

TargetMolReferences and Literature

1. Guzi TJ, et al. Mol Cancer Ther, 2011, 10(4), 591-602. 2. Montano R, et al. Mol Cancer Ther, 2012, 11(2), 427-438. 3. Schenk EL, et al. Clin Cancer Res, 2012, 18(19), 5364-5373. 4. Ou J, Li H, Qiu P, et al. CDK9 modulates circadian clock by attenuating REV-ERBα activity[J]. Biochemical and biophysical research communications. 2019 Jun 11;513(4):967-973.

TargetMolCitations

1. Ou J, Li H, Qiu P, et al. CDK9 modulates circadian clock by attenuating REV-ERBα activity. Biochemical and Biophysical Research Communications. 2019 Jun 11;513(4):967-973

Related compound libraries

This product is contained In the following compound libraries:
Anti-Cancer Active Compound Library Highly Selective Inhibitor Library Anti-Cancer Drug Library Anti-Cancer Clinical Compound Library Anti-Breast Cancer Compound Library Anti-Pancreatic Cancer Compound Library Kinase Inhibitor Library Hematonosis Compound Library Bioactive Compound Library Cell Cycle Compound Library

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CCT241533 hydrochloride Buddlejasaponin IV GDC0575 monohydrochloride BML-277 CHK1-IN-2 PF 477736 SAR-020106 A-443654

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Keywords

SCH900776 891494-63-6 Cell Cycle/Checkpoint CDK Chk SCH-900776 Inhibitor MK 8776 SCH 900776 Checkpoint Kinase (Chk) inhibit MK-8776 MK8776 inhibitor

 

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