Powder: -20°C for 3 years | In solvent: -80°C for 1 year
SCH900776 (MK-8776) is an agent targeting cell cycle checkpoint kinase 1 (Chk1) with potential radiosensitization and chemosensitization activities.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 48.00 | |
2 mg | In stock | $ 71.00 | |
5 mg | In stock | $ 117.00 | |
10 mg | In stock | $ 171.00 | |
25 mg | In stock | $ 297.00 | |
50 mg | In stock | $ 486.00 | |
100 mg | In stock | $ 695.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 126.00 |
Description | SCH900776 (MK-8776) is an agent targeting cell cycle checkpoint kinase 1 (Chk1) with potential radiosensitization and chemosensitization activities. |
Targets&IC50 | Chk1:3 nM, CDK2:0.16 μM |
Kinase Assay | The Millipore Kinase Profiler service is used to generate general selectivity data for SCH 900776 against a broad range of serine/threonine and tyrosine kinases. Assays are typically run at two concentrations of SCH 900776 (0.5 and 5 μM), at a fixed (10 μM) concentration of ATP. Data are provided as percent activity remaining, relative to uninhibited controls. |
Cell Research | For cell growth assays, cells are seeded at low density (500-1000 cells) in 96-well plates and then incubated with drug for 24 h (8 wells per concentration). Following treatment, cells are washed and grown in fresh media for 5-7 days at 37°C. Prior to attaining confluence, cells are washed, lysed, and stained with Hoechst 33258. Fluorescence is read on a microplate spectrofluorometer. Results are expressed as mean and standard error for the concentration of drug that inhibited growth by 50%. |
Synonyms | MK 8776, MK-8776 |
Molecular Weight | 376.25 |
Formula | C15H18BrN7 |
CAS No. | 891494-63-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 100 mg/mL (265.78 mM)
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
SCH900776 891494-63-6 Cell Cycle/Checkpoint CDK Chk SCH-900776 Inhibitor MK 8776 SCH 900776 Checkpoint Kinase (Chk) inhibit MK-8776 MK8776 inhibitor