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SIB-1757

Catalog No. T8434 CAS 31993-01-8

Synonyms: 6-methyl-2-[(E)-phenyldiazenyl]pyridin-3

SIB-1757 (6-methyl-2-[(E)-phenyldiazenyl]pyridin-3) is a selective antagonist of mGlu5 metabotropic glutamate receptor subtype (hmGlu5, IC50 : 0.4 μM)

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SIB-1757, CAS 31993-01-8

Pack Size	Availability	Price/USD
1 mg	In stock	$ 51.00
2 mg	In stock	$ 74.00
5 mg	In stock	$ 122.00
10 mg	In stock	$ 183.00
25 mg	In stock	$ 328.00
50 mg	In stock	$ 478.00
100 mg	In stock	$ 663.00
500 mg	In stock	$ 1,370.00
1 mL * 10 mM (in DMSO)	In stock	$ 116.00

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Purity: 98.49%

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Description	SIB-1757 (6-methyl-2-[(E)-phenyldiazenyl]pyridin-3) is a selective antagonist of mGlu5 metabotropic glutamate receptor subtype (hmGlu5, IC50 : 0.4 μM)
Targets&IC50	mGlu5 (human):0.4 μM
In vivo	SIB-1757 was given by either intrathecal (i.th.), subcutaneous (s.c.) or intraplantar (i.pl.) injection.?In SNL rats, i.th.?SIB-1757 produced a partial reversal of tactile allodynia with a shallow dose-response curve ranging over three-orders of magnitude;?SIB-1757 was inactive against allodynia when given systemically.?SIB-1757 produced full reversal of thermal hyperalgesia in SNL rats following administration either spinally or locally to the injured paw;?administration to the contralateral paw had no effect.?SIB-1757 did not produce antinociception in either the SNL or sham-operated rats by any route[1].

Synonyms	6-methyl-2-[(E)-phenyldiazenyl]pyridin-3
Molecular Weight	213.24
Formula	C12H11N3O
CAS No.	31993-01-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 17 mg/ml(79.72 mM)

References and Literature

1. Dogrul A , Ossipov M H , Lai J , et al. Peripheral and spinal antihyperalgesic activity of SIB-1757, a metabotropic glutamate receptor (mGLUR5) antagonist, in experimental neuropathic pain in rats[J]. 2000, 292(2):0-118. 2. Varney M A A , Cosford N D P , Jachec C , et al. SIB-1757 and SIB-1893: selective, noncompetitive antagonists of metabotropic glutamate receptor type 5[J]. Journal of Pharmacology & Experimental Therapeutics, 1999, 290(1):170-181.

Related compound libraries

This product is contained In the following compound libraries：

Highly Selective Inhibitor Library Inhibitor Library Anti-Neurodegenerative Disease Compound Library Glutamine Metabolism Compound Library Bioactive Compounds Library Max Neuronal Signaling Compound Library Neurotransmitter Receptor Compound Library Bioactive Compound Library

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Keywords

SIB-1757 31993-01-8 Neuroscience GluR mGluR 6-methyl-2-[(E)-phenyldiazenyl]pyridin-3 SIB 1757 Metabotropic glutamate receptors SIB1757 inhibit Inhibitor 6-methyl-2-[phenyldiazenyl]pyridin-3 inhibitor

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