Powder: -20°C for 3 years | In solvent: -80°C for 1 year
SID 26681509 is a selective, reversible and competitive human cathepsin L inhibitor (IC50 of 56 nM).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 60.00 | |
5 mg | In stock | $ 147.00 | |
10 mg | In stock | $ 228.00 | |
25 mg | In stock | $ 459.00 | |
50 mg | In stock | $ 687.00 | |
100 mg | In stock | $ 979.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 175.00 |
Description | SID 26681509 is a selective, reversible and competitive human cathepsin L inhibitor (IC50 of 56 nM). |
Targets&IC50 | Leishmania major:12.5 μM , Cathepsin L (human):56 nM , P. falciparum:15.4 μM |
In vitro | After a 4 hr preincubation with cathepsin L, SID 26681509 becomes more potent(IC50 : 1.0 nM). SID 26681509 is determined to be a slow-binding and slowly reversible competitive inhibitor. Through a transient kinetic analysis for single-step reversibility, inhibition rate constants are kon = 24,000 M-1s-1 and koff = 2.2 × 10-5 s-1 (Ki = 0.89 nM). Molecular docking studies are undertaken using the experimentally-derived X-ray crystal structure of papain/CLIK-148[1]. SID 26681509 inhibits papain and cathepsins B, K, S, and V with IC50 values determined after one hour ranging from 618 nM to 8.442 μM[1]. |
In vivo | survival in murine models of sepsis significantly improved SID 26681509 by and reduces liver damage following warm liver ischemia/reperfusion (I/R) models[2]. |
Molecular Weight | 539.65 |
Formula | C27H33N5O5S |
CAS No. | 958772-66-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 55 mg/ml (101.92 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. More
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SID 26681509 958772-66-2 Microbiology/Virology Proteases/Proteasome Cysteine Protease Parasite slow-binding falciparu Inhibitor propagation Leishmania major reversible Cathepsin inhibit SID26681509 Plasmodium SID-26681509 malaria Thiocarbazate inhibitor