Powder: -20°C for 3 years | In solvent: -80°C for 1 year
SNIPER(ER)-87 is a chemical compound composed of a derivative of the inhibitor of apoptosis protein (IAP) ligand LCL161 conjugated to the estrogen receptor α (ERα) ligand 4-hydroxytamoxifen using a PEG linker. It effectively degrades the ERα protein with an IC50 value of 0.097 μM. Within cells, SNIPER(ER)-87 selectively recruits XIAP to ERα, and XIAP functions as the primary E3 ubiquitin ligase responsible for the degradation of ERα induced by SNIPER(ER)-87[1][2].
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | 35 days | $ 1,070.00 |
Description | SNIPER(ER)-87 is a chemical compound composed of a derivative of the inhibitor of apoptosis protein (IAP) ligand LCL161 conjugated to the estrogen receptor α (ERα) ligand 4-hydroxytamoxifen using a PEG linker. It effectively degrades the ERα protein with an IC50 value of 0.097 μM. Within cells, SNIPER(ER)-87 selectively recruits XIAP to ERα, and XIAP functions as the primary E3 ubiquitin ligase responsible for the degradation of ERα induced by SNIPER(ER)-87[1][2]. |
In vitro | SNIPER(ER)-87, at concentrations ranging from 0.1 to 1000 nM over 72 hours, effectively suppresses ERα-dependent transcriptional activation induced by β-estradiol and inhibits the proliferation of ERα-positive breast cancer cells, achieving IC50 values of 15.6 nM in MCF-7 cells and 9.6 nM in T47D cells[1]. |
In vivo | SNIPER(ER)-87, administered intraperitoneally at a dosage of 30 mg/kg every 24 hours for a duration of 14 days, effectively suppresses the development of MCF-7 orthotopic breast tumor xenografts in six-week-old female BALB/c nude mice[1]. |
Molecular Weight | 1044.32 |
Formula | C59H73N5O10S |
CAS No. | 2222354-91-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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SNIPER(ER)-87 2222354-91-6 Others SNIPER(ER)87 SNIPER(ER) 87 inhibitor inhibit