Powder: -20°C for 3 years | In solvent: -80°C for 1 year
SR9011 is a REV-ERB agonist (IC50: 790 nM, REV-ERBα; IC50: 560 nM, REV-ERBβ).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 53.00 | |
2 mg | In stock | $ 76.00 | |
5 mg | In stock | $ 155.00 | |
10 mg | In stock | $ 273.00 | |
25 mg | In stock | $ 465.00 | |
50 mg | In stock | $ 682.00 | |
100 mg | In stock | $ 969.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 163.00 |
Description | SR9011 is a REV-ERB agonist (IC50: 790 nM, REV-ERBα; IC50: 560 nM, REV-ERBβ). |
Targets&IC50 | Rev-erbα:560 nM, REV-ERB:790 nM |
In vitro | SR9011 and SR9009 effectively inhibits transcription in a cotransfection assay using full-length REV-ERBα along with a luciferase reporter driven by the Bmal1 promoter (SR9011 IC50: 620 nM). SR9011 suppresses the expression of BMAL1 mRNA in HepG2 cells in a REV-ERBα/β-dependent manner. |
In vivo | SR9011 inhibits the activity of the SCN clock, with reversible inhibition of circadian oscillations in SCN explants cultured from the Per2: Luc reporter mouse. |
Molecular Weight | 479.04 |
Formula | C23H31ClN4O3S |
CAS No. | 1379686-29-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 43 mg/mL
You can also refer to dose conversion for different animals. More
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