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SR9238

Catalog No. T16930 CAS 1416153-62-2

SR9238 is a synthetic agonist of liver X receptor inverse (IC50s: 214 nM and 43 nM for LXRα and LXRβ, respectively).

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SR9238, CAS 1416153-62-2

Pack Size	Availability	Price/USD
2 mg	In stock	$ 41.00
5 mg	In stock	$ 67.00
10 mg	In stock	$ 117.00
25 mg	In stock	$ 237.00
50 mg	In stock	$ 417.00
1 mL * 10 mM (in DMSO)	In stock	$ 89.00

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Purity: 99.99%

Purity: 99.19%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	SR9238 is a synthetic agonist of liver X receptor inverse (IC50s: 214 nM and 43 nM for LXRα and LXRβ, respectively).
Targets&IC50	LXRβ:43 nM, LXRα:214 nM
In vitro	SR9238 effectively suppresses transcription from a fatty acid synthase promoter-driven luciferase reporter. SR9238 is a synthetic LXR inverse agonist (IC50s: 214 nM and 43 nM for LXRα and LXRβ, respectively). SR9238-induced recruitment of CoRNR box peptides is dose-dependent for both LXRα and LXRβ. It is found that SR9238 induces increased interaction of CoRNR box peptides derived from NCoR with both LXRα and LXRβ while causing decreased interaction with a coactivator NR box peptide derived from TRAP220. HepG2 cells treated with SR9238 cause a significant decrease in Fasn and Srebp1c mRNA expression[1].
In vivo	SR9238 treatment inhibits diet-induced hepatosteatosis, hepatic inflammation, and hepatocellular injury. SR9238 is also detected in the intestine with either i.p. or oral administration. Approximately SR9238 (6 μM) is detected in the liver 2h after the injection of SR9238, but no compound is detected in the plasma. SR9238-treated mice show greatly reduced lipid content in the liver. Both Tnfa and Il1b expression are substantially reduced (~80% and >95%, respectively) in the SR9238-treated mice when compared to the vehicle-treated mice. SR9238-treated DIO mice display a considerably lower intensity of F4/80 staining versus vehicle-treated DIO mice consistent with a beneficial effect of SR9238 on non-alcoholic steatohepatitis. SR9238 treatment does not alter body weight or percent body fat composition relative to vehicle-treated animals during the experiment [1].

Molecular Weight	595.73
Formula	C31H33NO7S2
CAS No.	1416153-62-2

Storage

store at low temperature

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 50 mg/mL (83.93 mM), Sonication is recommended.

References and Literature

1. Griffett K, et al. A liver-selective LXR inverse agonist that suppresses hepatic steatosis. ACS Chem Biol. 2013 Mar 15;8(3):559-67.

Related compound libraries

This product is contained In the following compound libraries：

Metabolism Compound Library Bioactive Compound Library Nuclear Receptor Compound Library Bioactive Compounds Library Max

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

SR9238 1416153-62-2 Metabolism Liver X Receptor SR 9238 Liver X receptor LXR inhibit SR-9238 Inhibitor inhibitor

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