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STF-31

Catalog No. T2363 CAS 724741-75-7

STF-31 is an inhibitor of glucose transporter 1 (GLUT1) with IC50 of 1 μM.

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STF-31, CAS 724741-75-7

Pack Size	Availability	Price/USD
1 mg	In stock	$ 32.00
2 mg	In stock	$ 46.00
5 mg	In stock	$ 74.00
10 mg	In stock	$ 115.00
25 mg	In stock	$ 243.00
50 mg	In stock	$ 459.00
100 mg	In stock	$ 673.00
500 mg	In stock	$ 1,420.00
1 mL * 10 mM (in DMSO)	In stock	$ 108.00

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Purity: 99.98%

Purity: 99.92%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	STF-31 is an inhibitor of glucose transporter 1 (GLUT1) with IC50 of 1 μM.
Targets&IC50	GLUT1:1 μM.
In vitro	STF-31 selectively kills RCCs by specifically targeting glucose uptake through GLUT1. STF-31 significantly inhibits lactate production and extracellular acidification in VHL-deficient cells by about 60%, and decreases glycolysis by decreasing glucose transport. [1] In NAPRT1-expressing cells, STF-31 shows cytotoxicity by inhibiting the enzymatic activity of NAMPT. [2] STF-31 is toxic to hPSCs and efficient for selective elimination of hPSCs from mixed cultures. [3]
In vivo	In mice with VHL-deficient RCC xenografts, a more soluble analog of STF-31 (11.6 mg/kg, i.p.) markedly delays tumor growth. [1]

Molecular Weight	423.53
Formula	C23H25N3O3S
CAS No.	724741-75-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Ethanol: 25 mg/mL (59.03 mM)

DMSO: 42.4 mg/mL(100 mM)

References and Literature

1. Chan DA, et al. Sci Transl Med. 2011, 3(94), 94ra70. 2. Adams DJ, et al. ACS Chem Biol. 2014, 9(10), 2247-2254. 3. Boheler KR, et al. Stem Cell Reports. 2014, 3(1), 185-203.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Anti-Cancer Active Compound Library Glutamine Metabolism Compound Library Autophagy Compound Library Bioactive Compounds Library Max Anti-Cancer Metabolism Compound Library Preclinical Compound Library Anti-Obesity Compound Library Target-Focused Phenotypic Screening Library Glycometabolism Compound Library

Related Products

Related compounds with same targets

WZB117 Glutaminase-IN-1 BAY-876 Dodoviscin H GLUT inhibitor-1 MitoPQ T-1095 DL-TBOA

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

STF-31 724741-75-7 Autophagy Metabolism transporter VHL inhibitor RCC4/VHL STF31 GLUT Glucose transporter GLUT1 inhibit glucose RCC4 STF 31

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