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STING agonist-3 trihydrochloride

Catalog No. T13014L   CAS T13014L
Synonyms: STING agonist-3 trihydrochloride (2138299-29-1 free base)

STING agonist-3 trihydrochloride is a selective and non-nucleotide agonist of small-molecule STING(pEC50 and pEC50 of 7.5 and 9.5, respectively), has durable anti-tumor effect and tremendous potential to improve treatment of cancer.

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STING agonist-3 trihydrochloride Chemical Structure
STING agonist-3 trihydrochloride, CAS T13014L
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Biological Description
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Description STING agonist-3 trihydrochloride is a selective and non-nucleotide agonist of small-molecule STING(pEC50 and pEC50 of 7.5 and 9.5, respectively), has durable anti-tumor effect and tremendous potential to improve treatment of cancer.
In vitro STING agonist-3 trihydrochloride exhibits activation of STING in cells(pEC50 of 7.5), this assay is determined using a luciferase reporter assay in human embryonic kidney cells (HEK293T) co-transfected with plasmids expressing STING and the enzyme firefly luciferase driven by the interferon stimulated response element promoter.In FRET assay, STING agonist-3 trihydrochloride exhibits a pIC50 value of 9.5. This is a competition binding assay which aims to determine the binding potency of molecules to the C-terminal Domain (CTD) of human STING.
Synonyms STING agonist-3 trihydrochloride (2138299-29-1 free base)
Molecular Weight 860.19
Formula C37H45Cl3N12O6
CAS No. T13014L

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

TargetMolReferences and Literature

1. Adam Kenneth, et al. Heterocyclic amides useful as protein modulators.patent WO2017175147A1

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Keywords

STING agonist-3 trihydrochloride T13014L Others STING agonist3 trihydrochloride STING agonist-3 STING agonist-3 Trihydrochloride STING agonist 3 trihydrochloride STING agonist-3 trihydrochloride (2138299-29-1 free base) 2138299-29-1 2138299-29-1 free base inhibitor inhibit

 

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