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SYR127063

Catalog No. T34760 CAS 871026-18-5

Synonyms: SYR-127063, BDBM 92454, SYR 127063, BDBM-92454, BDBM92454

SYR127063 (BDBM-92454) (BDBM92454) is a potent and selective HER2 inhibitor, binds to HER2 in a reactive conformation.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

SYR127063, CAS 871026-18-5

Pack Size	Availability	Price/USD
1 mg	In stock	$ 133.00
5 mg	In stock	$ 302.00
10 mg	In stock	$ 453.00
25 mg	In stock	$ 747.00
50 mg	In stock	$ 1,050.00
1 mL * 10 mM (in DMSO)	In stock	$ 373.00

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Purity: 98.57%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	SYR127063 (BDBM-92454) (BDBM92454) is a potent and selective HER2 inhibitor, binds to HER2 in a reactive conformation.
Targets&IC50	EGFR:429 nM, HER2:11 nM, HER4: > 10000 nM
In vitro	IC50 data: HER2 = 11 nM; EGFR = 429 nM; HER4 > 10000 nM

Synonyms	SYR-127063, BDBM 92454, SYR 127063, BDBM-92454, BDBM92454
Molecular Weight	492.88
Formula	C23H20ClF3N4O3
CAS No.	871026-18-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 55 mg/mL (111.59 mM)

H2O: Insoluble

References and Literature

1. Aertgeerts K, Skene R, Yano J, Sang BC, Zou H, Snell G, Jennings A, Iwamoto K, Habuka N, Hirokawa A, Ishikawa T, Tanaka T, Miki H, Ohta Y, Sogabe S. Structural analysis of the mechanism of inhibition and allosteric activation of the kinase domain of HER2 protein. J Biol Chem. 2011 May 27;286(21):18756-65. doi: 10.1074/jbc.M110.206193. Epub 2011 Mar 30. PubMed PMID: 21454582; PubMed Central PMCID: PMC3099692.

Related compound libraries

This product is contained In the following compound libraries：

Tyrosine Kinase Inhibitor Library Kinase Inhibitor Library Inhibitor Library Angiogenesis related Compound Library Anti-Colorectal Cancer Compound Library Anti-Lung Cancer Compound Library Anti-Pancreatic Cancer Compound Library Anti-Liver Cancer Compound Library Bioactive Compounds Library Max NO PAINS Compound Library

Related Products

Related compounds with same targets

EGFR-IN-89 A-935142 AV-412 EGFR/HER2/DHFR-IN-3 JCN037 lavendustin C (E)-AG 99 EGFR-IN-2

Dose Conversion

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Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

Note:

Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
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What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

SYR127063 871026-18-5 Angiogenesis JAK/STAT signaling Tyrosine Kinase/Adaptors EGFR HER SYR-127063 BDBM 92454 SYR 127063 BDBM-92454 BDBM92454 inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.