Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Saclofen is a sulfonic analog of the inhibitory neurotransmitter γ-aminobutyric acid (GABA) that acts as a competitive antagonist of the GABAB receptor (IC50: 7.8 μM).1 This compound can be used to determine the functional roles for the GABAB receptor as a mediator of slow inhibitory postsynaptic potentials in the brain.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 51.00 | |
5 mg | In stock | $ 122.00 | |
10 mg | In stock | $ 197.00 | |
25 mg | In stock | $ 455.00 | |
50 mg | In stock | $ 672.00 | |
100 mg | In stock | $ 956.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 116.00 |
Description | Saclofen is a sulfonic analog of the inhibitory neurotransmitter γ-aminobutyric acid (GABA) that acts as a competitive antagonist of the GABAB receptor (IC50: 7.8 μM).1 This compound can be used to determine the functional roles for the GABAB receptor as a mediator of slow inhibitory postsynaptic potentials in the brain. |
Targets&IC50 | GABAB:7.8 μM |
In vivo | CCT241736 significantly inhibited the growth of MV4-11 human FLT3-ITD positive AML tumor xenografts in vivo, with biomarker modulation and free drug exposure consistent with dual FLT3 and Aurora kinase target inhibition |
Molecular Weight | 249.71 |
Formula | C9H12ClNO3S |
CAS No. | 125464-42-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 5.5 mg/mL (22.03 mM)
You can also refer to dose conversion for different animals. More
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Saclofen 125464-42-8 Membrane transporter/Ion channel Neuroscience GABA Receptor Gamma-aminobutyric acid Receptor γ-Aminobutyric acid Receptor Inhibitor inhibit inhibitor