Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Sacubitrilat (LBQ-657) (LBQ657) is an effective inhibitor of active neprilysin (NEP).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 41.00 | |
2 mg | In stock | $ 57.00 | |
5 mg | In stock | $ 97.00 | |
10 mg | In stock | $ 163.00 | |
25 mg | In stock | $ 363.00 | |
50 mg | In stock | $ 578.00 | |
100 mg | In stock | $ 833.00 | |
500 mg | In stock | $ 1,690.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 97.00 |
Description | Sacubitrilat (LBQ-657) (LBQ657) is an effective inhibitor of active neprilysin (NEP). |
In vitro | Sacubitrilat is bound to the active site of NEP by an intricate network of interactions that involves all functional groups of the compound giving rise to the high inhibitory potency of 5?nM [1]. |
In vivo | Pharmacokinetics of Sacubitril, Sacubitrilat, and valsartan following the administration of single oral doses of LCZ696 400 or 1200 mg under fasting conditions are summarized. The mean plasma concentrations of Sacubitril increases rapidly with a median Tmax of 0.52 h for the 400 mg dose and 1.05 h for the 1200 mg dose, followed by Sacubitrilat, with the corresponding Tmax values of 2.07 and 3.05 h, respectively. The median Tmax for valsartan is 2.07 h for both the LCZ696 400 mg and 1200 mg doses. The Cmax of Sacubitrilat shows a dose-proportional increase, while the Cmax of Sacubitril and Valsartan shows less than proportional increases between the doses [2]. |
Synonyms | LBQ-657 |
Molecular Weight | 383.44 |
Formula | C22H25NO5 |
CAS No. | 149709-44-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 100 mg/mL (260.80 mM)
You can also refer to dose conversion for different animals. More
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Sacubitrilat 149709-44-4 Metabolism Neprilysin Desethyl Sacubitril NEP Neutral endopeptidase LBQ-657 Inhibitor inhibit LBQ657 LBQ 657 CD10 Cluster of differentiation 10 inhibitor