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Salermide

Catalog No. T3953 CAS 1105698-15-4

Salermide is an inhibitor of Sirt1 and Sirt2, causing strong cancer-specific apoptotic cell death.

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Salermide, CAS 1105698-15-4

Pack Size	Availability	Price/USD
5 mg	In stock	$ 47.00
10 mg	In stock	$ 67.00
25 mg	In stock	$ 147.00
50 mg	In stock	$ 257.00
100 mg	In stock	$ 457.00
500 mg	In stock	$ 987.00
1 mL * 10 mM (in DMSO)	In stock	$ 52.00

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Purity: 99.55%

Purity: 97.62%

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Storage & Solubility Information

Description	Salermide is an inhibitor of Sirt1 and Sirt2, causing strong cancer-specific apoptotic cell death.
In vitro	Salermide prompts tumour-specific cell death in a wide range of human cancer cell lines. The antitumour activity of Salermide is primarily because of a massive induction of apoptosis. Salermide induces apoptosis in cancer but not in normal cells. It induces strong apoptosis without any evident effect on the cell cycle in all the cancer cell lines analysed except in non-tumorigenic MRC5 cells. The induction of apoptosis is cell-type-specific and dose-dependent[1].
In vivo	Salermide is well tolerated by mice at concentrations up to 100?μM. Its feeding does not produce any adverse health effects in mice as monitored by diet consumption, body-weight gain, and postural and behavioural changes[1].
Cell Research	Cell viability is determined using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay as described earlier. IC50 index is calculated using four Salermide concentrations (25, 50, 75 and 100?μm) for 24?h. The percentage of apoptotic cells is determined with the FACSCalibur apparatus.(Only for Reference)

Molecular Weight	394.47
Formula	C26H22N2O2
CAS No.	1105698-15-4

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 39.5 mg/mL (100 mM)

References and Literature

1. Lara E, et al. Oncogene. 2009, 28(6):781-91.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Active Compound Library Inhibitor Library Hematonosis Compound Library Apoptosis Compound Library NO PAINS Compound Library Anti-Diabetic Compound Library Histone Modification Compound Library Epigenetics Compound Library Anti-COVID-19 Compound Library Glutamine Metabolism Compound Library

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Keywords

Salermide 1105698-15-4 Apoptosis Chromatin/Epigenetic DNA Damage/DNA Repair Sirtuin Inhibitor inhibit inhibitor

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