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SantacruzaMate A

Catalog No. T2266 CAS 1477949-42-0

Synonyms: CAY-10683

SantacruzaMate A (CAY-10683) is a potent and selective HDAC inhibitor.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

SantacruzaMate A, CAS 1477949-42-0

Pack Size	Availability	Price/USD
2 mg	In stock	$ 30.00
5 mg	In stock	$ 45.00
10 mg	In stock	$ 53.00
25 mg	In stock	$ 113.00
50 mg	In stock	$ 207.00
100 mg	In stock	$ 311.00
1 mL * 10 mM (in DMSO)	In stock	$ 50.00

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Purity: 99.55%

Purity: 99.16%

Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	SantacruzaMate A (CAY-10683) is a potent and selective HDAC inhibitor.
Targets&IC50	HDAC2:119 pM
In vivo	Santacruzamate A inhibits the growth of HCT116 colon cancer cells and HuT-78 cutaneous T-cell lymphoma cells, with GI50 values of 29.4 μM and 1.4 μM, respectively.
Kinase Assay	HDAC Enzyme Assay: The commercially availablae human recombinant enzyme and fluorogenic HDAC assay kits have used to measure percent inhibition and IC50 values of three HDAC isozymes (HDAC2, HDAC4, HDAC6). Briefly, the inhibitor is added sequentially to a black, flat-bottom 96-well microtiter plate, and the reaction mixture is incubated for 30 min at 37°C. The potent HDAC inhibitor trichostatin A (included in the assay kit) is added to the bifunctional HDAC assay developer at a final reaction concentration of 1 μM to stop deacetylation and initiate the release of the fluorophore. The reaction mixture is further incubated at room temperature for 15 min. Fluorescence is measured on a Spectra Max Gemini XPS using an excitation wavelength of 360 nm and a detection wavelength of 460 nm.
Cell Research	HuT-78 cells incubated in Iscove’s modified Dulbecco’s medium supplemented with 20% FBS, 1% penicillin/streptomycin, and 1% L-glutamine. HCT-116 cells cultivated using McCoy’s 5A medium supplemented with 10% FBS, 1% penicillin/streptomycin, and 1% nonessential amino acids. Cells were seeded in a 96-well plate at 5000cells per well. Before treatment, the plates were incubated at 37°C, 5% CO2 for 24 h. Treatment with inhibitors were incubated in wells for 72 or 96 h using SAHA as a positive control. Antiproliferative activity was determined using a standard MTS-PMS assay. (Only for Reference)

Synonyms	CAY-10683
Molecular Weight	278.35
Formula	C15H22N2O3
CAS No.	1477949-42-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 51 mg/mL (183.2 mM)

Ethanol: 51 mg/mL (183.2 mM)

References and Literature

1. Pavlik CM, et al. J Nat Prod. 2013, 76(11), 2026-2033.

Citations

1. Wang C, Huang M, Lin Y, et al.ENO2-derived phosphoenolpyruvate functions as an endogenous inhibitor of HDAC1 and confers resistance to antiangiogenic therapy.Nature Metabolism.2023: 1-22. 2. Qin Y, Liu Q, Wang S, et al.Santacruzamate A Alleviates Pain and Pain-Related Adverse Emotions through the Inhibition of Microglial Activation in the Anterior Cingulate Cortex.ACS Pharmacology & Translational Science.2024

Related compound libraries

This product is contained In the following compound libraries：

Highly Selective Inhibitor Library Microbial Natural Product Library Inhibitor Library Chromatin Modification Compound Library NO PAINS Compound Library NF-κB Signaling Compound Library Immunology/Inflammation Compound Library DNA Damage & Repair Compound Library Anti-Aging Compound Library Anti-Cancer Compound Library

Related Products

Related compounds with same targets

Sinapinic Acid JPS014 TFA Nexturastat A LMK-235 Scriptaid HDAC1/CDK7-IN-1 GK444 NKL 22

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

SantacruzaMate A 1477949-42-0 Chromatin/Epigenetic DNA Damage/DNA Repair HDAC Inhibitor inhibit Histone deacetylases CAY-10683 CAY10683 CAY 10683 inhibitor

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