Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Sapanisertib (INK 128) is an orally bioavailable inhibitor of raptor-mTOR (TOR complex 1 or TORC1) and rictor-mTOR (TOR complex 2 or TORC2) with potential antineoplastic activity.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 34.00 | |
2 mg | In stock | $ 47.00 | |
5 mg | In stock | $ 77.00 | |
10 mg | In stock | $ 97.00 | |
25 mg | In stock | $ 163.00 | |
50 mg | In stock | $ 247.00 | |
100 mg | In stock | $ 369.00 | |
500 mg | In stock | $ 883.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 81.00 |
Description | Sapanisertib (INK 128) is an orally bioavailable inhibitor of raptor-mTOR (TOR complex 1 or TORC1) and rictor-mTOR (TOR complex 2 or TORC2) with potential antineoplastic activity. |
Targets&IC50 | mTOR:1.4 nM(Ki), PI3Kγ:221 nM, PI3Kα:219 nM, PI3Kδ:230 nM |
Kinase Assay | mTOR activity is assayed using LanthaScreen Kinase kit reagents. PI(3)K α, β, γ and δ activity are assayed using the PI(3)K HTRF assay kit. The concentration of INK128 necessary to achieve inhibition of enzyme activity by 50% (IC50) is calculated using concentrations ranging from 20 μM to 0.1 nM (12-point curve). IC50?values are determined using a nonlinear regression model. |
Cell Research | PC3 cells are treated with the appropriate drug for 48 h, and proliferation is measured using CellTiter-Glo Luminescent reagent. The concentration of INK128 necessary to achieve inhibition of cell growth by 50% (IC50) is calculated using concentrations ranging from 20.0 μM to 0.1 nM (12-point curve). |
Synonyms | TAK-228, MLN0128, INK 128 |
Molecular Weight | 309.33 |
Formula | C15H15N7O |
CAS No. | 1224844-38-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ethanol: 2 mg/mL (6.46 mM)
DMSO: 58 mg/mL (187.5 mM)
H2O: < 1 mg/mL (insoluble or slightly soluble)
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Sapanisertib 1224844-38-5 Autophagy PI3K/Akt/mTOR signaling PI3K mTOR MLN 0128 INK128 TAK-228 inhibit TAK 228 INK-128 MLN0128 TAK228 INK 128 Mammalian target of Rapamycin MLN-0128 Inhibitor inhibitor