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Sapanisertib

Catalog No. T1838   CAS 1224844-38-5
Synonyms: TAK-228, MLN0128, INK 128

Sapanisertib (INK 128) is an orally bioavailable inhibitor of raptor-mTOR (TOR complex 1 or TORC1) and rictor-mTOR (TOR complex 2 or TORC2) with potential antineoplastic activity.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
Sapanisertib Chemical Structure
Sapanisertib, CAS 1224844-38-5
Pack Size Availability Price/USD Quantity
1 mg In stock $ 34.00
2 mg In stock $ 47.00
5 mg In stock $ 77.00
10 mg In stock $ 97.00
25 mg In stock $ 163.00
50 mg In stock $ 247.00
100 mg In stock $ 369.00
500 mg In stock $ 883.00
1 mL * 10 mM (in DMSO) In stock $ 81.00
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Purity: 100%
Purity: 99.34%
Purity: 98.72%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Sapanisertib (INK 128) is an orally bioavailable inhibitor of raptor-mTOR (TOR complex 1 or TORC1) and rictor-mTOR (TOR complex 2 or TORC2) with potential antineoplastic activity.
Targets&IC50 mTOR:1.4 nM(Ki), PI3Kγ:221 nM, PI3Kα:219 nM, PI3Kδ:230 nM
Kinase Assay mTOR activity is assayed using LanthaScreen Kinase kit reagents. PI(3)K α, β, γ and δ activity are assayed using the PI(3)K HTRF assay kit. The concentration of INK128 necessary to achieve inhibition of enzyme activity by 50% (IC50) is calculated using concentrations ranging from 20 μM to 0.1 nM (12-point curve). IC50?values are determined using a nonlinear regression model.
Cell Research PC3 cells are treated with the appropriate drug for 48 h, and proliferation is measured using CellTiter-Glo Luminescent reagent. The concentration of INK128 necessary to achieve inhibition of cell growth by 50% (IC50) is calculated using concentrations ranging from 20.0 μM to 0.1 nM (12-point curve).
Synonyms TAK-228, MLN0128, INK 128
Molecular Weight 309.33
Formula C15H15N7O
CAS No. 1224844-38-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Ethanol: 2 mg/mL (6.46 mM)

DMSO: 58 mg/mL (187.5 mM)

H2O: < 1 mg/mL (insoluble or slightly soluble)

TargetMolReferences and Literature

1. Liu A, et al. Drug Discovery Today: Therapeutic Strategies. 2009, 6(2), 47-55. 2. Jessen K, et al. Mol Cancer Ther. 2009, 8(12), Meeting Abstract Supplement. 3. Hsieh AC, et al. Nature. 2012, 485(7396), 55-61. 4. Zhao, Ming, et al. GCG inhibits SARS-CoV-2 replication by disrupting the liquid phase condensation of its nucleocapsid protein. Nature Communications . 12.1 (2021): 1-14.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Cancer Clinical Compound Library Highly Selective Inhibitor Library Anti-Cancer Drug Library Anti-Cancer Active Compound Library Inhibitor Library Cancer Cell Differentiation Compound Library Clinical Compound Library ReFRAME Related Library Orally Active Compound Library Reprogramming Compound Library

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Keywords

Sapanisertib 1224844-38-5 Autophagy PI3K/Akt/mTOR signaling PI3K mTOR MLN 0128 INK128 TAK-228 inhibit TAK 228 INK-128 MLN0128 TAK228 INK 128 Mammalian target of Rapamycin MLN-0128 Inhibitor inhibitor

 

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