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Saponarin

Catalog No. TN2179 CAS 20310-89-8

Synonyms: Petrocomoside, Saponaretin-7-O-glucoside, Isovitexin-7-O-glucoside

Saponarin (Petrocomoside) shows in vitro and in vivo hepatoprotective and antioxidant activity against CCl4-induced liver damage.

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Saponarin, CAS 20310-89-8

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Purity: 98.84%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Saponarin (Petrocomoside) shows in vitro and in vivo hepatoprotective and antioxidant activity against CCl4-induced liver damage.

In vitro

In freshly isolated rat hepatocytes, paracetamol (100 μ mol) led to a significant decrease in cell viability, increased LDH leakage, decreased levels of cellular GSH, and elevated MDA quantity. Saponarin (60-0.006 μ g/mL) preincubation, however, significantly ameliorated paracetamol-induced hepatotoxicity in a concentration-dependent manner. The beneficial effect of Saponarin was also observed in vivo. Rats were challenged with paracetamol alone (600 mg/kg, i.p.) and after 7-day pretreatment with Saponarin (80 mg/kg, oral gavage). Paracetamol toxicity was evidenced by increase in MDA quantity and decrease in cell GSH levels and antioxidant defence system. No changes in phase I enzyme activities of AH and EMND and cytochrome P 450 quantity were detected. Saponarin pretreatment resulted in significant increase in cell antioxidant defence system and GSH levels and decrease in lipid peroxidation. The biochemical changes are in good correlation with the histopathological data. Protective activity of Saponarin was similar to the activity of positive control silymarin[1].

Synonyms	Petrocomoside, Saponaretin-7-O-glucoside, Isovitexin-7-O-glucoside
Molecular Weight	594.52
Formula	C27H30O15
CAS No.	20310-89-8

Storage

store at low temperature,keep away from direct sunlight

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 90 mg/mL (151.4 mM), Sonication is recommended.

References and Literature

1. Hepatoprotective and antioxidant effects of saponarin, isolated from Gypsophila trichotoma Wend. on paracetamol-induced liver damage in rats.Biomed Res Int. 2013;2013:757126.

Related compound libraries

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Keywords

Saponarin 20310-89-8 Chromatin/Epigenetic MAPK Metabolism NF-Κb PI3K/Akt/mTOR signaling P450 NF-κB ERK AMPK Petrocomoside Saponaretin-7-O-glucoside Isovitexin-7-O-glucoside inhibitor inhibit

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