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Saquinavir

Catalog No. T7903 CAS 127779-20-8

Synonyms: Ro 31-8959, 沙奎那韦

Saquinavir is a potent HIV protease inhibitor, is an antiretroviral drug used together with other medications to treat or prevent HIV/AIDS.

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Saquinavir, CAS 127779-20-8

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Purity: 98%

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Storage & Solubility Information

Description	Saquinavir is a potent HIV protease inhibitor, is an antiretroviral drug used together with other medications to treat or prevent HIV/AIDS.
In vivo	The AUC was not affected by grapefruit juice after intravenous administration, but it increased significantly from 76+/-96 (water, mean (s.d.) to 114+/-70 (microg l[-1] h) (grapefruit juice) after oral saquinavir. Similarly, the oral bioavailability of saquinavir increased by a factor of 2 with grapefruit juice (from 0.7% to 1.4%). In contrast, clearance, volume of distribution and elimination half-life of saquinavir were not affected by grapefruit juice. After oral, but not after intravenous administration, the plasma concentration-time curve showed a second peak after lunch irrespective of pretreatment, suggesting enhancement of absorption by food[1].
Animal Research	After an overnight fast, eight healthy volunteers were treated with either 400 ml grapefruit juice or water before intravenous (12 mg) or oral saquinavir (600 mg) was administered.?Serial blood samples were obtained over the following 24 h and standardized meals were served 5 and 10 h after the administration of saquinavir.?The plasma concentrations of saquinavir were determined by high-performance liquid chromatography and pharmacokinetic parameters were calculated by routine methods[1].

Synonyms	Ro 31-8959, 沙奎那韦
Molecular Weight	670.855
Formula	C38H50N6O5
CAS No.	127779-20-8

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 100 mg/mL (149.07 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Kupferschmidt H H T , Fattinger K E , Ha H R , et al. Grapefruit juice enhances the bioavailability of HIV protease inhibitor saquinavir in man[J]. British Journal of Clinical Pharmacology, 1998, 45(4):355-359. 2. Walmsley S , Avihingsanon A , Slim J , et al. Gemini: A Noninferiority Study of Saquinavir/Ritonavir Versus Lopinavir/Ritonavir as Initial HIV-1 Therapy in Adults[J]. JAIDS Journal of Acquired Immune Deficiency Syndromes, 2009, 50(4):367-374.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Drug-induced Liver Injury (DILI) Compound Library Drug Repurposing Compound Library FDA-Approved Drug Library Anti-COVID-19 Compound Library Anti-Viral Compound Library Approved Drug Library FDA-Approved & Pharmacopeia Drug Library Protease Inhibitor Library Bioactive Compound Library

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Keywords

Saquinavir 127779-20-8 蛋白酶体微生物学 HIV Protease SARS-CoV HIV Human immunodeficiency virus Inhibitor inhibit SARS coronavirus Ro 31-8959 inhibitor

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