Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Scoulerine is an inhibitor of ß-site amyloid precursor protein cleaving enzyme 1(BACE1). Scoulerine a potent antimitotic compound that inhibits proliferation, arrests cell cycle, and induces apoptosis in cancer cells.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 213.00 | |
2 mg | In stock | $ 318.00 | |
5 mg | In stock | $ 535.00 | |
10 mg | In stock | $ 763.00 | |
25 mg | In stock | $ 1,130.00 | |
50 mg | In stock | $ 1,550.00 |
Description | Scoulerine is an inhibitor of ß-site amyloid precursor protein cleaving enzyme 1(BACE1). Scoulerine a potent antimitotic compound that inhibits proliferation, arrests cell cycle, and induces apoptosis in cancer cells. |
In vitro | Forty-six isoquinoline alkaloids, of eleven structural types isolated in our laboratory, have been evaluated for their cytotoxicity against two cancer cell lines (Caco-2 and Hep-G2 cancer cells), as well as against normal human lung fibroblast cells. Only Scoulerine, aromoline, berbamine and parfumidine showed significant cytotoxic effects, but only Scoulerine was active against both Caco-2 and Hep-G2 cells (IC50 values 6.44 ± 0.87 and 4.57 ± 0.42, respectively). Unfortunately, except for parfumidine, the other active alkaloids were also cytotoxic to the normal human lung fibroblast cells[1] |
Source |
Molecular Weight | 327.37 |
Formula | C19H21NO4 |
CAS No. | 6451-73-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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Scoulerine 6451-73-6 Apoptosis Microbiology/Virology Neuroscience BACE Beta-Secretase Parasite proliferation Inhibitor cancer Beta-secretase inhibit microtubule cycle β-Secretase Microtubule/Tubulin leukemic cells division mitotic Discretamine inhibitor