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Senexin A

Catalog No. T5673 CAS 1366002-50-7

Senexin A is an effective and selective CDK8 inhibitor that also inhibits CDK19 with Kd values of 0.83 microns and 0.31 microns, respectively.

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Senexin A, CAS 1366002-50-7

Pack Size	Availability	Price/USD
1 mg	In stock	$ 51.00
2 mg	In stock	$ 72.00
5 mg	In stock	$ 116.00
10 mg	In stock	$ 168.00
25 mg	In stock	$ 328.00
50 mg	In stock	$ 597.00
100 mg	In stock	$ 852.00
1 mL * 10 mM (in DMSO)	In stock	$ 113.00

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Senexin A is an effective and selective CDK8 inhibitor that also inhibits CDK19 with Kd values of 0.83 microns and 0.31 microns, respectively.
Targets&IC50	CDK19:0.31 μm, CDK8:0.83 μM
In vitro	Senexin A inhibited CDK8 and CDK19 ATP site binding with Kd50 of 0.83 μM and 0.31 μM, respectively and CDK8 kinase activity with IC50 of 0.28 μM.CDK8 stimulates Wnt/β-catenin, and Senexin A inhibits β-catenin–dependent transcription in HCT116 colon carcinoma cells.
In vivo	Administering Senexin A daily for five days completely counteracts the tumor-promoting effects of chemotherapy, displaying no detectable toxicity or significant impacts on body weight, organ weights, or blood cell counts in C57BL/6 mice. The adverse effects of doxorubicin treatment are entirely negated when followed by Senexin A administration, significantly enhancing the responsiveness of A549/MEF tumors to doxorubicin.
Animal Research	Tumor-free C57BL/6-derived SCID mice were injected with a single dose of doxorubicin or carrier control.?Five days later, mice received. injection of 2 × 10^6 human A549 lung carcinoma cells, and tumor take was measured over 4 wk.

Molecular Weight	274.32
Formula	C17H14N4
CAS No.	1366002-50-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 100 mg/mL (364.54 mM)

References and Literature

1. Porter D C , Farmaki E , Altilia S , et al. Cyclin-dependent kinase 8 mediates chemotherapy-induced tumor-promoting paracrine activities[J]. Proceedings of the National Academy of Sciences, 2012, 109(34):13799-13804.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Anti-Cancer Compound Library Bioactive Compounds Library Max Cell Cycle Compound Library Kinase Inhibitor Library Anti-Breast Cancer Compound Library Anti-Pancreatic Cancer Compound Library NO PAINS Compound Library Bioactive Compound Library Anti-Aging Compound Library

Related Products

Related compounds with same targets

Palbociclib monohydrochloride Flavopiridol JSH-150 THZ1-R CGP60474 Voruciclib HQ461 CDK2-IN-4

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Senexin A 1366002-50-7 Cell Cycle/Checkpoint CDK Cyclin dependent kinase Inhibitor inhibit inhibitor

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