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Serotonin hydrochloride

Catalog No. T2209   CAS 153-98-0
Synonyms: 5-HT hydrochloride, 5-HT HCl, Serotonin HCl, 5-Hydroxytryptamine hydrochloride

Serotonin hydrochloride (Serotonin HCl) is an endogenous 5-HT receptor agonist, a monoamine neurotransmitter in the CNS, and a catechol O-methyltransferase (COMT) inhibitor(Ki=44 μM).

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Serotonin hydrochloride Chemical Structure
Serotonin hydrochloride, CAS 153-98-0
Pack Size Availability Price/USD Quantity
25 mg In stock $ 30.00
50 mg In stock $ 42.00
100 mg In stock $ 52.00
200 mg In stock $ 72.00
1 mL * 10 mM (in DMSO) In stock $ 47.00
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Purity: 99.93%
Purity: 99.86%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Serotonin hydrochloride (Serotonin HCl) is an endogenous 5-HT receptor agonist, a monoamine neurotransmitter in the CNS, and a catechol O-methyltransferase (COMT) inhibitor(Ki=44 μM).
Targets&IC50 COMT:44 μM(Ki)
In vivo The role of serotonin in the regulation of larval Aedes aegypti hemolymph composition is investigated in vivo using two reuptake inhibitors (SSRIs), alaproclate HCl and 6-nitroquipazine maleate, and the receptor antagonist methiothepin mesylate. [1]
Synonyms 5-HT hydrochloride, 5-HT HCl, Serotonin HCl, 5-Hydroxytryptamine hydrochloride
Molecular Weight 212.676
Formula C10H13ClN2O
CAS No. 153-98-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: 21.3 mg/mL (100 mM)

DMSO: 21.3 mg/mL (100 mM)

TargetMolReferences and Literature

1. Onken, H, et al. J Insect Sci, 2008, 8, 1-20. 2. Han M, Kang F, Yang C, et al. A comparative study of serotonin and norepinephrine as adjuncts to improve cutaneous antinociception of mexiletine in response to skin pinpricks in rats[J]. International Journal of Immunopathology and Pharmacology. 2021, 35: 20587384211016129. 3. Ping Liu, Yu-ling Yin, Ting Wang, Li Hou, Xiao-xi Wang, Man Wang, Guan-guan Zhao, Yi Shi, H. Eric Xu, and Yi Jiang. Ligand-induced activation of ERK1/2 signaling by constitutively active Gs-coupled 5-HT receptors [J]. Acta Pharmacologica Sinica. 2019 Mar 4.

TargetMolCitations

1. Liu P, Yin Y, Wang T, et al. Ligand-induced activation of ERK1/2 signaling by constitutively active Gs-coupled 5-HT receptors. Acta Pharmacologica Sinica. 2019, 40(9): 1157-1167 2. Han M, Kang F, Yang C, et al. A comparative study of serotonin and norepinephrine as adjuncts to improve cutaneous antinociception of mexiletine in response to skin pinpricks in rats. International Journal of Immunopathology and Pharmacology. 2021, 35: 20587384211016129.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Cancer Clinical Compound Library Anti-Cancer Drug Library Human Endogenous Metabolite Library Anti-Neurodegenerative Disease Compound Library Anti-Cancer Approved Drug Library Drug-Fragment Library Angiogenesis related Compound Library Human Endogenous Metabolite Compound Library Plus Anti-Parkinson's Disease Compound Library Natural Product Library

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Keywords

Serotonin hydrochloride 153-98-0 GPCR/G Protein Metabolism Neuroscience 5-HT Receptor Endogenous Metabolite Transferase 5-HT hydrochloride Serotonin Serotonin Receptor 5-hydroxytryptamine Receptor 5-Hydroxytryptamine Hydrochloride COMT 5-HT 5-HT HCl Serotonin HCl Inhibitor 5-Hydroxytryptamine Serotonin Hydrochloride 5-Hydroxytryptamine hydrochloride inhibit 5-HT Hydrochloride inhibitor

 

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