Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Sodium dichloroacetate (BCA) , a specific inhibitor of pyruvate dehydrogenase kinase (PDK) with IC50 values of 183 and 80 μM for PDK2 and PDK4 respectively, has been shown to derepress a mitochondrial potassium-ion channel axis, trigger apoptosis in cancer cells, and inhibit tumor growth.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
50 mg | In stock | $ 31.00 | |
100 mg | In stock | $ 45.00 | |
200 mg | In stock | $ 58.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 50.00 |
Description | Sodium dichloroacetate (BCA) , a specific inhibitor of pyruvate dehydrogenase kinase (PDK) with IC50 values of 183 and 80 μM for PDK2 and PDK4 respectively, has been shown to derepress a mitochondrial potassium-ion channel axis, trigger apoptosis in cancer cells, and inhibit tumor growth. |
Targets&IC50 | PDK2:183 μM, PDK4:80 μM |
Synonyms | Sodium Dichloroacetate, DCA, BCA, bichloroacetic acid, Sodium dichloroacetate (DCA) |
Molecular Weight | 150.92 |
Formula | C2HCl2NaO2 |
CAS No. | 2156-56-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: 166.66 mg/mL (1104.3 mM), Sonication is recommended.
DMSO: 15.1 mg/mL(100 mM)
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Sodium dichloroacetate 2156-56-1 Apoptosis Immunology/Inflammation Metabolism NF-Κb PI3K/Akt/mTOR signaling Reactive Oxygen Species Dehydrogenase PDK lactic pyruvate PDH kinase Sodium Dichloroacetate ROS acid mitochondria PDHK DCA Anticancer inhibit NKCC BCA bichloroacetic acid metabolic dehydrogenase Inhibitor Sodium dichloroacetate (DCA) Pyruvate dehydrogenase kinase inhibitor