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Sofalcone

Catalog No. T4977   CAS 64506-49-6
Synonyms: SU-88

Sofalcone (SU-88), a gastric antiulcer agent in clinical use, is known to induce the expression of Heme oxygenase-1 (HO-1) in gastric epithelium.

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Sofalcone Chemical Structure
Sofalcone, CAS 64506-49-6
Pack Size Availability Price/USD Quantity
100 mg In stock $ 48.00
200 mg In stock $ 59.00
500 mg In stock $ 81.00
1 g In stock $ 117.00
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Purity: 99.40%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Sofalcone (SU-88), a gastric antiulcer agent in clinical use, is known to induce the expression of Heme oxygenase-1 (HO-1) in gastric epithelium.
In vitro Sofalcone (50 μmol/L) significantly increases HO-1 mRNA expression than the control group in both trophoblasts and HUVECs (P<0.05 for both). Western blot analysis shows that Sofalcone potently increases HO-1 protein expression in primary HUVECs treated for 24 hours. Western blot analysis also reveals a significant increase in the amount of Nrf2 in the nuclear fraction of HUVECs with Sofalcone treatment (50 μmol/L) for 6 hours. In primary HUVECs, expression of NQO1, TXN, and GCLC are increased in a dose dependently manner with Sofalcone treatment for 24 hours. Sofalcone significantly decreases the sFlt-1 concentrations in the culture media and dose dependently decreases the amount of THP-1 monocyte adherence to HUVECs.
Cell Research Primary HUVECs are seeded at 60?000 cells per well and incubated at 37°C for 14 to 16 hours to allow tube formation. Cells are then cultured in the presence of either TNF-α (10 ng/mL) alone, with both TNF-α (10 ng/mL) and Sofalcone 50 μM, or control media for 8 to 12 hours. Tube formation is assessed, and images are captured using microscope at ×4 magnification.
Synonyms SU-88
Molecular Weight 450.52
Formula C27H30O6
CAS No. 64506-49-6

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 50 mg/mL (110.98 mM)

TargetMolReferences and Literature

1. Onda K, et al. Sofalcone upregulates the nuclear factor (erythroid-derived 2)-like 2/heme oxygenase-1 pathway, reduces soluble fms-like tyrosine kinase-1, and quenches endothelial dysfunction: potential therapeutic for preeclampsia. Hypertension. 2015 Apr;65(4):855-62.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Cancer Approved Drug Library Anti-Cancer Drug Library Human Metabolite Library Anti-Aging Compound Library FDA-Approved & Pharmacopeia Drug Library Bioactive Compounds Library Max Immunology/Inflammation Compound Library Nonsteroidal Anti-Inflammatory Compound Library Approved Drug Library Bioactive Compound Library

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Keywords

Sofalcone 64506-49-6 Autophagy Microbiology/Virology Antibacterial inhibit SU-88 Bacterial SU88 SU 88 Inhibitor inhibitor

 

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