Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Sofalcone (SU-88), a gastric antiulcer agent in clinical use, is known to induce the expression of Heme oxygenase-1 (HO-1) in gastric epithelium.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
100 mg | In stock | $ 48.00 | |
200 mg | In stock | $ 59.00 | |
500 mg | In stock | $ 81.00 | |
1 g | In stock | $ 117.00 |
Description | Sofalcone (SU-88), a gastric antiulcer agent in clinical use, is known to induce the expression of Heme oxygenase-1 (HO-1) in gastric epithelium. |
In vitro | Sofalcone (50 μmol/L) significantly increases HO-1 mRNA expression than the control group in both trophoblasts and HUVECs (P<0.05 for both). Western blot analysis shows that Sofalcone potently increases HO-1 protein expression in primary HUVECs treated for 24 hours. Western blot analysis also reveals a significant increase in the amount of Nrf2 in the nuclear fraction of HUVECs with Sofalcone treatment (50 μmol/L) for 6 hours. In primary HUVECs, expression of NQO1, TXN, and GCLC are increased in a dose dependently manner with Sofalcone treatment for 24 hours. Sofalcone significantly decreases the sFlt-1 concentrations in the culture media and dose dependently decreases the amount of THP-1 monocyte adherence to HUVECs. |
Cell Research | Primary HUVECs are seeded at 60?000 cells per well and incubated at 37°C for 14 to 16 hours to allow tube formation. Cells are then cultured in the presence of either TNF-α (10 ng/mL) alone, with both TNF-α (10 ng/mL) and Sofalcone 50 μM, or control media for 8 to 12 hours. Tube formation is assessed, and images are captured using microscope at ×4 magnification. |
Synonyms | SU-88 |
Molecular Weight | 450.52 |
Formula | C27H30O6 |
CAS No. | 64506-49-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 50 mg/mL (110.98 mM)
You can also refer to dose conversion for different animals. More
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