Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Sotagliflozin (LP-802034) is an orally bioavailable inhibitor of the sodium-glucose co-transporter subtype 1 (SGLT1) and 2 (SGLT2), with potential antihyperglycemic activity.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 38.00 | |
2 mg | In stock | $ 52.00 | |
5 mg | In stock | $ 89.00 | |
10 mg | In stock | $ 133.00 | |
25 mg | In stock | $ 261.00 | |
50 mg | In stock | $ 397.00 | |
100 mg | In stock | $ 590.00 | |
500 mg | In stock | $ 1,260.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 90.00 |
Description | Sotagliflozin (LP-802034) is an orally bioavailable inhibitor of the sodium-glucose co-transporter subtype 1 (SGLT1) and 2 (SGLT2), with potential antihyperglycemic activity. |
Targets&IC50 | SGLT2:1.8 nM, SGLT1:36 nM |
In vitro | LX4211 inhibits [14C]AMG uptake with IC50 of 62.0 nM for mouse SGLT1 and 0.6 nM for mouse SGLT2, respectively. [2] |
In vivo | In mice, LX4211 (60 mg/kg, p.o.) reduces intestinal glucose absorption by inhibiting SGLT1, resulting in net increases in GLP-1 and PYY release and decreases in GIP release and blood glucose excursions. [2] In nonobese diabetes-prone mice with type 1 diabetes, Sotagliflozin (30 mg/kg) significantly improves glycemic control, without increasing the rate of hypoglycemia measurements. [3] |
Synonyms | LX-4211, LP-802034 |
Molecular Weight | 424.94 |
Formula | C21H25ClO5S |
CAS No. | 1018899-04-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 78 mg/mL (183.6 mM)
H2O: < 1 mg/mL (insoluble or slightly soluble)
Ethanol: 14 mg/mL (32.9 mM)
You can also refer to dose conversion for different animals. More
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Sotagliflozin 1018899-04-1 GPCR/G Protein SGLT inhibit LX4211 LX-4211 Inhibitor LP-802034 LP 802034 Sodium-dependent glucose cotransporters LX 4211 LP802034 inhibitor