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Src Inhibitor 1

Catalog No. T3593 CAS 179248-59-0

Synonyms: Src Kinase Inhibitor 1, Src-l1

Src Inhibitor 1 (Src Kinase Inhibitor 1) is a potent and selective dual site Src tyrosine kinase inhibitor.

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Src Inhibitor 1, CAS 179248-59-0

Pack Size	Availability	Price/USD
1 mg	In stock	$ 33.00
2 mg	In stock	$ 44.00
5 mg	In stock	$ 67.00
10 mg	In stock	$ 92.00
25 mg	In stock	$ 217.00
50 mg	In stock	$ 392.00
100 mg	In stock	$ 575.00
500 mg	In stock	$ 1,220.00
1 mL * 10 mM (in DMSO)	In stock	$ 54.00

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Purity: 100%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Src Inhibitor 1 (Src Kinase Inhibitor 1) is a potent and selective dual site Src tyrosine kinase inhibitor.
Targets&IC50	Lck:88nM, Src:44 nM
In vitro	Src-I1 is competitive with both ATP and peptide binding sites of the kinase. The IC50 values are 44 and 88 nM for Src and Lck, respectively[1]. Src-I1, is found to be a potent inhibitor of Src (IC50=0.18 μM), but also inhibited other Src family members, such as Lck, Csk and Yes with similar potency to Src, and RIP2 (IC50=0.026 μM) with even greater potency. In addition, it inhibited CHK2 with similar potency to Src, and Aurora B with slightly lower potency[2].
Kinase Assay	Assays (25.5 μL volume) are carried out robotically at room temperature (21°C) and are linear with respect to time and enzyme concentration under the conditions used. Assays are performed for 30 min using Multidrop Micro reagent dispensers in a 96-well format. The concentration of magnesium acetate in the assays is 10 mM and [γ-33P]ATP (800 c.p.m./pmol) is used at 5, 20 or 50 μM as indicated, in order to be at or below the Kmfor ATP for each enzyme.The assays are initiated with MgATP, stopped by the addition of 5 μL of 0.5 M orthophosphoric acid and spotted on to P81 filter plates using a unifilter harvester. The IC50 values of inhibitors are determined after carrying out assays at ten different concentrations of each compound[2].

Synonyms	Src Kinase Inhibitor 1, Src-l1
Molecular Weight	373.4
Formula	C22H19N3O3
CAS No.	179248-59-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 3.73 mg/mL (10 mM), Sonication is recommended.

References and Literature

1. Tian G, et al. Structural determinants for potent, selective dual site inhibition of human pp60c-src by 4-anilinoquinazolines. Biochemistry. 2001 Jun 19;40(24):7084-91. 2. Bain J, et al. The selectivity of protein kinase inhibitors: a further update. Biochem J. 2007 Dec 15;408(3):297-315.

Related compound libraries

This product is contained In the following compound libraries：

Tyrosine Kinase Inhibitor Library Inhibitor Library Bioactive Compounds Library Max Angiogenesis related Compound Library Reprogramming Compound Library Anti-Pancreatic Cancer Compound Library HIF-1 Signaling Pathway Compound Library NO PAINS Compound Library Bioactive Compound Library Kinase Inhibitor Library

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5Z-7-Oxozeaenol Tirbanibulin Repotrectinib MNS HPK1-IN-2 Agerafenib Rigosertib PP121

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Src Inhibitor 1 179248-59-0 Angiogenesis Tyrosine Kinase/Adaptors Src Src Kinase Inhibitor1 Inhibitor Src Kinase Inhibitor-1 Src Kinase Inhibitor 1 Src-l1 Src Inhibitor1 inhibit Src Inhibitor-1 inhibitor

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