Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Stachydrine (N,N-Dimethyl-L-proline) is a major constituent of Chinese herb leonurus heterophyllus sweet used to promote blood circulation and dispel blood stasis. Stachydrine (N,N-Dimethyl-L-proline) can inhibit the NF-κB signal pathway. Stachydrine (N,N-Dimethyl-L-proline) is a biomarker for the consumption of citrus fruits.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | In stock | $ 31.00 | |
10 mg | In stock | $ 48.00 | |
25 mg | In stock | $ 75.00 | |
50 mg | In stock | $ 101.00 | |
100 mg | In stock | $ 140.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 37.00 |
Description | Stachydrine (N,N-Dimethyl-L-proline) is a major constituent of Chinese herb leonurus heterophyllus sweet used to promote blood circulation and dispel blood stasis. Stachydrine (N,N-Dimethyl-L-proline) can inhibit the NF-κB signal pathway. Stachydrine (N,N-Dimethyl-L-proline) is a biomarker for the consumption of citrus fruits. |
In vitro | Various concentrations of stachydrine intervention (10(-6) - 10(-4) mol/L) showed better anti-hypertrophic effect and decreased the number of ROS positive myocardial cell (P<0.05). Meanwhile, intervention of stachydrine significantly suppressed the level of p-IkappaB (ser32) protein in the cytosol and NF-kappaB (p65) protein in the nucleus (P<0.05). |
Cell Research | Myocardial cells of neonatal rats were incubated with angiotensin II for 48 hours to establish myocardial cell hypertrophy models. The cell surface area and protein/DNA ratio were detected as index for hypertrophy of myocardial cells. ROS positive myocardial cell were counted by means of flow cytometry, the expression of p-IkappaB (ser32) protein in the cytosol and NF-kappaB (p65) protein in the nucleus were also detected by Western blot. |
Synonyms | Methyl hygrate betaine, L-stachydrine, Proline betaine, N,N-Dimethyl-L-proline |
Molecular Weight | 143.18 |
Formula | C7H13NO2 |
CAS No. | 471-87-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 26 mg/mL (181.59 mM)
H2O: 32 mg/mL (223.49 mM)
You can also refer to dose conversion for different animals. More
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Stachydrine 471-87-4 Metabolism NF-Κb NF-κB Endogenous Metabolite Methyl hygrate betaine Inhibitor Nuclear factor-κB L-stachydrine Proline betaine inhibit Nuclear factor-kappaB N,N-Dimethyl-L-proline inhibitor