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Stachydrine

Catalog No. T5769   CAS 471-87-4
Synonyms: Methyl hygrate betaine, L-stachydrine, Proline betaine, N,N-Dimethyl-L-proline

Stachydrine (N,N-Dimethyl-L-proline) is a major constituent of Chinese herb leonurus heterophyllus sweet used to promote blood circulation and dispel blood stasis. Stachydrine (N,N-Dimethyl-L-proline) can inhibit the NF-κB signal pathway. Stachydrine (N,N-Dimethyl-L-proline) is a biomarker for the consumption of citrus fruits.

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Stachydrine Chemical Structure
Stachydrine, CAS 471-87-4
Pack Size Availability Price/USD Quantity
5 mg In stock $ 31.00
10 mg In stock $ 48.00
25 mg In stock $ 75.00
50 mg In stock $ 101.00
100 mg In stock $ 140.00
1 mL * 10 mM (in DMSO) In stock $ 37.00
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Purity: 98%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Stachydrine (N,N-Dimethyl-L-proline) is a major constituent of Chinese herb leonurus heterophyllus sweet used to promote blood circulation and dispel blood stasis. Stachydrine (N,N-Dimethyl-L-proline) can inhibit the NF-κB signal pathway. Stachydrine (N,N-Dimethyl-L-proline) is a biomarker for the consumption of citrus fruits.
In vitro Various concentrations of stachydrine intervention (10(-6) - 10(-4) mol/L) showed better anti-hypertrophic effect and decreased the number of ROS positive myocardial cell (P<0.05). Meanwhile, intervention of stachydrine significantly suppressed the level of p-IkappaB (ser32) protein in the cytosol and NF-kappaB (p65) protein in the nucleus (P<0.05).
Cell Research Myocardial cells of neonatal rats were incubated with angiotensin II for 48 hours to establish myocardial cell hypertrophy models. The cell surface area and protein/DNA ratio were detected as index for hypertrophy of myocardial cells. ROS positive myocardial cell were counted by means of flow cytometry, the expression of p-IkappaB (ser32) protein in the cytosol and NF-kappaB (p65) protein in the nucleus were also detected by Western blot.
Synonyms Methyl hygrate betaine, L-stachydrine, Proline betaine, N,N-Dimethyl-L-proline
Molecular Weight 143.18
Formula C7H13NO2
CAS No. 471-87-4

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 26 mg/mL (181.59 mM)

H2O: 32 mg/mL (223.49 mM)

TargetMolReferences and Literature

1. Guo W , Zhang C , Liao Y L , et al. [Effect of Leonurus stachydrine on myocardial cell hypertrophy][J]. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials, 2012, 35(6):940-943.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Aging Compound Library Inhibitor Library Human Endogenous Metabolite Compound Library Plus Anti-Prostate Cancer Compound Library Gut Microbial Metabolite Library Anti-Diabetic Compound Library Anti-Pancreatic Cancer Compound Library Anti-Lung Cancer Compound Library Bioactive Compounds Library Max Human Metabolite Library

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Keywords

Stachydrine 471-87-4 Metabolism NF-Κb NF-κB Endogenous Metabolite Methyl hygrate betaine Inhibitor Nuclear factor-κB L-stachydrine Proline betaine inhibit Nuclear factor-kappaB N,N-Dimethyl-L-proline inhibitor

 

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