Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Streptolydigin inhibits RNA synthesis by binding to RNA polymerase and does not inhibit eukaryotic RNA polymerases. Streptolydigin is a 3-acetyltetramic acid antibiotic and a potent bacterial RNA polymerase inhibitor (Ki: 18 μM and a Kd: 15 μM).
Pack Size | Availability | Price/USD | Quantity |
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25 mg | Inquiry | $ 1,520.00 |
Description | Streptolydigin inhibits RNA synthesis by binding to RNA polymerase and does not inhibit eukaryotic RNA polymerases. Streptolydigin is a 3-acetyltetramic acid antibiotic and a potent bacterial RNA polymerase inhibitor (Ki: 18 μM and a Kd: 15 μM). |
Targets&IC50 | Bacterial RNA polymerase:(ki)18 μM |
In vitro | Streptolydigin inhibits initiation, elongation, and pyrophosphorolysis by bacterial RNA polymerase. Streptolydigin inhibits T. thermophilus RNA polymerase (a Ki: 1.8 μM). Binding of Streptolydigin to RNA polymerase strictly depends on a noncatalytic magnesium ion which is likely chelated by the aspartate of the bridge helix of the active center. Streptolydigin interacts with three structural elements within RNAP: the Stl pocket, the bridge helix, and the trigger-loop region. The Streptolydigin streptolol moiety interacts with the Streptolydigin pocket and bridge helix, and the Streptolydigin tetramic-acid moiety interacts with the trigger-loop region [1][3]. |
Synonyms | Portamycin |
Molecular Weight | 600.7 |
Formula | C32H44N2O9 |
CAS No. | 7229-50-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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Streptolydigin 7229-50-7 Microbiology/Virology Antibacterial Portamycin inhibitor inhibit