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Substance P

Catalog No. TP1087   CAS 33507-63-0
Synonyms: Neurokinin P

Substance P (Neurokinin P) (SP) is an undecapeptide (a peptide composed of a chain of 11 amino acid residues) member of the tachykinin neuropeptide family.

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Substance P Chemical Structure
Substance P, CAS 33507-63-0
Pack Size Availability Price/USD Quantity
1 mg In stock $ 52.00
5 mg In stock $ 118.00
10 mg In stock $ 188.00
25 mg In stock $ 400.00
50 mg In stock $ 595.00
100 mg In stock $ 849.00
1 mL * 10 mM (in DMSO) In stock $ 313.00
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Purity: 98%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Substance P (Neurokinin P) (SP) is an undecapeptide (a peptide composed of a chain of 11 amino acid residues) member of the tachykinin neuropeptide family.
In vitro The desensitization and resensitization of neuropeptide substance P (SP) mediated by neurokinin 1 receptor (NK1-R), which may be associated with NK1-R endocytosis and recycling. SP and the NK1-R are internalized into the same clathrin immunoreactive vesicles, and then sorted into different compartments. SP is intact at the cell surface and in early endosomes, but slowly degraded in perinuclear vesicles. SP induces clathrin-dependent internalization of the NK1-R. The SP/NK1-R complex dissociates in acidified endosomes. SP is degraded, whereas the NK1-R recycles to the cell surface. SP induces internalization of the NK1-R both in transfected epithelial cells[1].
Synonyms Neurokinin P
Molecular Weight 1347.63
Formula C63H98N18O13S
CAS No. 33507-63-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 10mM

TargetMolReferences and Literature

1. Grady EF, et al. Delineation of the endocytic pathway of substance P and its seven-transmembrane domain NK1 receptor. Mol Biol Cell. 1995 May;6(5):509-24.

Related compound libraries

This product is contained In the following compound libraries:
Peptide Compound Library Anti-Cancer Clinical Compound Library Anti-Cancer Drug Library Human Endogenous Metabolite Library NO PAINS Compound Library Bioactive Compounds Library Max Human Endogenous Metabolite Compound Library Plus Anti-Cancer Compound Library Anti-Hypertension Compound Library Bioactive Compound Library

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Scyliorhinin II acetate Eledoisin N-Acetyl-L-tryptophan Neurokinin A Senktide acetate CS-003 Free base [D-Pro2] Spantide I TFA GR-73632

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Keywords

Substance P 33507-63-0 GPCR/G Protein Metabolism Neuroscience Endogenous Metabolite Neurokinin receptor Neurokinin P Tachykinin receptor Neurokinin Receptor Inhibitor NK receptor inhibit inhibitor

 

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