Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Substance P (Neurokinin P) (SP) is an undecapeptide (a peptide composed of a chain of 11 amino acid residues) member of the tachykinin neuropeptide family.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 52.00 | |
5 mg | In stock | $ 118.00 | |
10 mg | In stock | $ 188.00 | |
25 mg | In stock | $ 400.00 | |
50 mg | In stock | $ 595.00 | |
100 mg | In stock | $ 849.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 313.00 |
Description | Substance P (Neurokinin P) (SP) is an undecapeptide (a peptide composed of a chain of 11 amino acid residues) member of the tachykinin neuropeptide family. |
In vitro | The desensitization and resensitization of neuropeptide substance P (SP) mediated by neurokinin 1 receptor (NK1-R), which may be associated with NK1-R endocytosis and recycling. SP and the NK1-R are internalized into the same clathrin immunoreactive vesicles, and then sorted into different compartments. SP is intact at the cell surface and in early endosomes, but slowly degraded in perinuclear vesicles. SP induces clathrin-dependent internalization of the NK1-R. The SP/NK1-R complex dissociates in acidified endosomes. SP is degraded, whereas the NK1-R recycles to the cell surface. SP induces internalization of the NK1-R both in transfected epithelial cells[1]. |
Synonyms | Neurokinin P |
Molecular Weight | 1347.63 |
Formula | C63H98N18O13S |
CAS No. | 33507-63-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 10mM
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Substance P 33507-63-0 GPCR/G Protein Metabolism Neuroscience Endogenous Metabolite Neurokinin receptor Neurokinin P Tachykinin receptor Neurokinin Receptor Inhibitor NK receptor inhibit inhibitor