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Sulfinpyrazone

Catalog No. T0435   CAS 57-96-5
Synonyms: (+/-)-Sulfinpyrazone, G-28315, NSC 75925

Sulfinpyrazone (NSC-75925) is a uricosuric drug that is used to reduce the serum urate levels in gout therapy. It lacks anti-inflammatory, analgesic, and diuretic properties.

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Sulfinpyrazone Chemical Structure
Sulfinpyrazone, CAS 57-96-5
Pack Size Availability Price/USD Quantity
100 mg In stock $ 43.00
200 mg In stock $ 58.00
500 mg In stock $ 93.00
1 g In stock $ 135.00
1 mL * 10 mM (in DMSO) In stock $ 48.00
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Purity: 98.1%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Sulfinpyrazone (NSC-75925) is a uricosuric drug that is used to reduce the serum urate levels in gout therapy. It lacks anti-inflammatory, analgesic, and diuretic properties.
In vivo Sulfinpyrazone exerts significant electrophysiologic actions under various experimental conditions. It raises the ventricular fibrillation threshold as well as the mid diastolic threshold and prolongs the effective refractory period. In the acutely ischemic heart, it attenuates the effect of coronary occlusion on the ventricular fibrillation threshold but has no effect after reperfusion. A protective influence of the drug is also evident during sympathetic humoral stimulation with norepinephrine. The antifibrillatory effect of sulfinpyrazone is additive to the changes elicited by beta adrenergic blockade with practolol or cardiac membrane stabilization with lidocaine[1].
Synonyms (+/-)-Sulfinpyrazone, G-28315, NSC 75925
Molecular Weight 404.48
Formula C23H20N2O3S
CAS No. 57-96-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Ethanol: 64 mg/mL (158.23 mM)

DMSO: 73 mg/mL(180.5 mM)

TargetMolReferences and Literature

1. Raeder EA, et al. Am J Cardiol. 1982, 50(2):271-275. 2. Rosenberg JC, et al. Arch Surg. 1975, 110(8):980-983.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Cancer Drug Library Anti-Cancer Approved Drug Library Anti-Cancer Compound Library Nonsteroidal Anti-Inflammatory Compound Library Approved Drug Library Anti-Metabolism Disease Compound Library Anti-Aging Compound Library Inhibitor Library FDA-Approved & Pharmacopeia Drug Library Bioactive Compound Library

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Keywords

Sulfinpyrazone 57-96-5 Immunology/Inflammation Neuroscience COX gouty (+/-)-Sulfinpyrazone G28315 uricosuric intermittent antithrombotic G 28315 oral G-28315 arthritis platelet NSC-75925 inhibit NSC 75925 NSC75925 Inhibitor inhibitor

 

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