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Sulindac sulfone

Catalog No. T23403   CAS 59864-04-9

Sulindac sulfone is a metabolite of the nonsteroidal anti-inflammatory drug sulindac. Sulindac sulfone is an inhibitor of aldose reductase (IC50 =367 nM).

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Sulindac sulfone Chemical Structure
Sulindac sulfone, CAS 59864-04-9
Pack Size Availability Price/USD Quantity
5 mg In stock $ 50.00
10 mg In stock $ 75.00
25 mg In stock $ 128.00
50 mg In stock $ 192.00
100 mg In stock $ 287.00
200 mg In stock $ 431.00
1 mL * 10 mM (in DMSO) In stock $ 50.00
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Purity: 98.19%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Sulindac sulfone is a metabolite of the nonsteroidal anti-inflammatory drug sulindac. Sulindac sulfone is an inhibitor of aldose reductase (IC50 =367 nM).
Targets&IC50 Aldose reductase:367 nM
In vitro In vitro: Sulindac sulfone treatment also inhibited PGE2 production by HCA-7 cells with an IC50 of 360 mmol/L. Sulindac sulfone at 100 mmol/L reduced 6-ketoPGFα by 29.2%. Sulindac sulfone reduced the colony number of HCA-7 and HCT-116 with an EC50 of 50 mmol/l. Sulindac sulfone significantly decreased the expression of total cellular β-catenin (50% of control), pro-caspase 3 (49%), cyclin D1 (51%), and PPARδ (65%) in SW480 cells. No significant alteration in pro-caspase 3 or β-catenin expression was found in HCA7, LS174, or Caco-2 cells treated with sulindac sulfone. A dose-dependent reduction in TCF-mediated transcriptional activity was also observed in SW480 cells [1][2].
In vivo In vivo: Sulindac sulfone is capable of reducing the incidence, multiplicity, and tumor burden in the azoxymethane AOM rat model of colorectal cancer. Sulindac sulfone had no effect on the growth of HCA-7, HCT-116 xenografts, and cancer cell xenografts [1].
Molecular Weight 372.41
Formula C20H17FO4S
CAS No. 59864-04-9

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: < 2.54 mg/mL

DMSO: ≥9.53 mg/mL, with ultrasonic and warmingmg

Ethanol: ≥3.83 mg/mL, with ultrasonic and warmingmg

TargetMolReferences and Literature

1. Zheng X, et al. The molecular basis for inhibition of sulindac and its metabolites towards human aldose reductase. FEBS Lett. 2012 Jan 2;586(1):55-9. 2. Kitamura S, Tatsumi K. In vitro metabolism of sulindac and sulindac sulfide: enzymatic formation of sulfoxide and sulfone. Jpn J Pharmacol. 1982 Oct;32(5):833-8. 3. Piazza GA, et al. Sulindac sulfone inhibits azoxymethane-induced colon carcinogenesis in rats without reducing prostaglandin levels. Cancer Res. 1997 Jul 15;57(14):2909-15. 4. Sauter A, et al. Sulindac sulfone induces a decrease of beta-catenin in HNSCC. Anticancer Res. 2010 Feb;30(2):339-43.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Cancer Clinical Compound Library Anti-Cancer Drug Library Anti-Cancer Active Compound Library Anti-Pancreatic Cancer Compound Library Pyroptosis Compound Library Endocrinology-Hormone Compound Library Metabolism Compound Library Anti-Cancer Compound Library Anti-Prostate Cancer Compound Library Anti-Lung Cancer Compound Library

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Keywords

Sulindac sulfone 59864-04-9 Endocrinology/Hormones Immunology/Inflammation Metabolism Neuroscience COX Reductase Aldose Reductase inhibit Exisulind Inhibitor inhibitor

 

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