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Suloctidil

Catalog No. T0712 CAS 54767-75-8

Suloctidil is a peripheral vasodilator that was formerly used in the management of peripheral and cerebral vascular disorders. It is hepatotoxic and fatalities have occurred.

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Suloctidil, CAS 54767-75-8

Pack Size	Availability	Price/USD
100 mg	In stock	$ 254.00
200 mg	In stock	$ 428.00
1 mL * 10 mM (in DMSO)	In stock	$ 89.00

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Purity: 99.79%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Suloctidil is a peripheral vasodilator that was formerly used in the management of peripheral and cerebral vascular disorders. It is hepatotoxic and fatalities have occurred.

Kinase Assay

Protein Kinase profiling assay: Assay for 22 different proteins kinases is carried out by ProQinase Gmbh. All of the protein kinases are expressed either in Sf9 insect cells or in E.coli as recombinant GST-fusion proteins or His-tagged proteins. Protein kinases are purified by affinity chromatography using either GSH-agarose or Ni_NTH-agarose. A radiometric protein kinase assay is used for measuring the kinase activity of the 22 protein kinases. Briefly, for each protein kinase, 50 μL reaction cocktail containing 60 mM HEPES-NaOH, 3 mM MgCl2, 3 mM MnCl2, 3 μM Na-orthovanadate, 1.2 mM DTT, 50 μg/mL PEG20000, 1 μM [γ-33P]-ATP, Niclosamide, adequate amount of enzyme and its substrate. The PKC-alpha assay additionally contain 1 mM Cacl2, 4 mM EDTA, 5 μg/mL phosphatidylserine and 1 μg/mL 1, 2-Dioleyl-glycerol. The reaction cocktails are incubated at 37 °C for 60 minutes and stop with 50 μL 2% (v/v) H3PO4. Incorporation of 33Pi is determined with a microplate scintillation counter. The activities and the IC50 values are calculated using Quattro Workflow V2.28.

Molecular Weight	337.56
Formula	C20H35NOS
CAS No.	54767-75-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 50 mg/mL (148.12 mM)

References and Literature

1. Ishibashi A, et al. Nihon Yakurigaku Zasshi. 1983 Nov;82(5):361-73.

Citations

1. Su C, Cheng C, Rong Z, et al.Repurposing fluphenazine as an autophagy modulator for treating liver cancer.Heliyon.2023

Related compound libraries

This product is contained In the following compound libraries：

NO PAINS Compound Library ReFRAME Related Library Mitochondria-Targeted Compound Library Ion Channel Inhibitor Library Bioactive Compounds Library Max Bioactive Compound Library Anti-Cancer Compound Library Human Metabolite Library Coagulation and Anticoagulation Compound Library Anti-COVID-19 Compound Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Suloctidil 54767-75-8 Membrane transporter/Ion channel Others ATPase Platelet aggregation Inhibitor Na+/K+ ATPase inhibit Sodium potassium pump inhibitor

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.