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T0070907

Catalog No. T6689 CAS 313516-66-4

T0070907(IC50=1 nM) , an effective and specific PPARγ inhibitor, with the <800-fold selectivity over PPARα and PPARδ.

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T0070907, CAS 313516-66-4

Pack Size	Availability	Price/USD
5 mg	In stock	$ 45.00
10 mg	In stock	$ 53.00
25 mg	In stock	$ 93.00
50 mg	In stock	$ 150.00
100 mg	In stock	$ 207.00
200 mg	In stock	$ 269.00
500 mg	In stock	$ 453.00
1 mL * 10 mM (in DMSO)	In stock	$ 50.00

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Purity: 99.95%

Purity: 99.36%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	T0070907(IC50=1 nM) , an effective and specific PPARγ inhibitor, with the >800-fold selectivity over PPARα and PPARδ.
Targets&IC50	PPARγ:1 nM
In vivo	T0070907 can attenuate the beneficial effects of lipopolysaccharide pretreatment, such as significantly improving renal insufficiency, reducing hepatocyte damage and circulatory failure, and reducing plasma interleukin-1 elevation caused by severe endotoxemia.
Kinase Assay	Ligand Binding Assay: To determine the binding affinity of T0070907 to the PPARs, scintillation proximity assay (SPA) is performed with the following modifications. A 90-μl reaction contains SPA buffer (10 mm KH2PO4, 10 mm KH2PO4, 2 mm EDTA, 50 mm NaCl, 1 mm dithiothreitol, 2 mmCHAPS, 10% (v/v) glycerol, pH 7.1), 50 ng of GST-PPARγ (or 150 ng of GST-PPARα, GST-PPARδ), 5 nm 3H-labeled radioligands, and 5 μl of T0070907 in Me2SO. After incubation for 1 h at room temperature, 10 μl of polylysine-coated SPA beads (at 20 mg/ml in SPA buffer) are added, and the mixtureis incubated for 1 h before reading in Packard Topcount. [3H]Rosiglitazone is used for PPARγ, and [3H]GW2433 is used for PPARα and PPARδ.
Cell Research	MTS assay(Only for Reference)

Molecular Weight	277.66
Formula	C12H8ClN3O3
CAS No.	313516-66-4

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 27.8 mg/mL (100 mM)

1eq. HCl: 27.8 mg/mL (100 mM)

References and Literature

1. Lee G et al. J Biol Chem, 2002, 277(22), 19649-19657. 2. Zaytseva YY et al. Anticancer Res, 2011, 31(3), 813-823. 3. Collin M et al. Crit Care Med, 2006, 34(4), 1131-1138.

Citations

1. Ren Q, Xie X, Zhao C, et al. 2, 2′, 4, 4′-Tetrabromodiphenyl Ether (PBDE 47) Selectively Stimulates Proatherogenic PPARγ Signatures in Human THP-1 Macrophages to Contribute to Foam Cell Formation. Chemical Research in Toxicology. 2022

Related compound libraries

This product is contained In the following compound libraries：

Highly Selective Inhibitor Library Inhibitor Library Anti-Neurodegenerative Disease Compound Library Toxic Compound Library Lipid Metabolism Compound Library Anti-Diabetic Compound Library Anti-Cancer Compound Library Bioactive Lipid Compound Library Anti-Hypertension Compound Library Bioactive Compound Library

Related Products

Related compounds with same targets

GW 501516 Glabridin Mifobate GW1929 Fonadelpar Glycyrin Rosiglitazone maleate Adelmidrol

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Keywords

T0070907 313516-66-4 DNA Damage/DNA Repair Metabolism PPAR inhibit T 0070907 Inhibitor T-0070907 Peroxisome proliferator-activated receptors inhibitor

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.