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T863

Catalog No. T4681 CAS 701232-20-4

Synonyms: DGAT-3, DGAT-1 inhibitor

T-863(DGAT-1 inhibitor) is an orally active, selective and potent DGAT1 (Acyl-CoA:diacylglycerol acyltransferase 1) inhibitor that interacts with the acyl-CoA binding site of DGAT1, and inhibits triacylglycerol synthesis in cells. IC50 value: Target: DGAT1 T863 (DGAT-3) causes weight loss, reduction in serum and liver triglycerides, and improved insulin sensitivity in obese mice.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

T863, CAS 701232-20-4

Pack Size	Availability	Price/USD
1 mg	In stock	$ 32.00
2 mg	In stock	$ 45.00
5 mg	In stock	$ 74.00
10 mg	In stock	$ 108.00
25 mg	In stock	$ 243.00
50 mg	In stock	$ 405.00
100 mg	In stock	$ 590.00
1 mL * 10 mM (in DMSO)	In stock	$ 81.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description

Synonyms	DGAT-3, DGAT-1 inhibitor
Molecular Weight	394.47
Formula	C22H26N4O3
CAS No.	701232-20-4

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 45 mg/mL (114.08 mM)

References and Literature

1. Cao J, et al. Targeting Acyl-CoA:diacylglycerol acyltransferase 1 (DGAT1) with small molecule inhibitors for the treatment of metabolic diseases. J Biol Chem. 2011 Dec 2;286(48):41838-51. 2. Dow RL, et al. Design and synthesis of potent, orally-active DGAT-1 inhibitors containing a dioxino[2,3-d]pyrimidine core. Bioorg Med Chem Lett. 2011 Oct 15;21(20):6122-5. 3. Qian Y, et al. Discovery of orally active carboxylic acid derivatives of 2-phenyl-5-trifluoromethyloxazole-4-carboxamide as potent diacylglycerol acyltransferase-1 inhibitors for the potential treatment of obesity and diabetes. J Med Chem. 2011 Apr 14;54(7):2433-46.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Orally Active Compound Library Anti-Obesity Compound Library Lipid Metabolism Compound Library NO PAINS Compound Library Bioactive Compound Library ReFRAME Related Library Bioactive Compounds Library Max Metabolism Compound Library Anti-Metabolism Disease Compound Library

Related Products

Related compounds with same targets

RHC 80267 RP 70676 Cyclandelate YM17E RU-SKI 43 Rimonabant K-604 dihydrochloride VULM 1457

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

T863 701232-20-4 Metabolism Acyltransferase Transferase Diglyceride acyltransferase inhibit acyl-CoA:cholesterol acyltransferase T 863 Inhibitor DGAT-3 DGAT-1 inhibitor T-863 mono- acylglycerol acyltransferase DGAT3 DGAT 3 Diacylglycerol acyltransferase inhibitor

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.