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TA-01

Catalog No. T4645   CAS 1784751-18-3

TA-01 is a potent CK1 and p38 MAPK inhibitor, with IC50s of 6.4 nM, 6.8 nM, 6.7 nM for CK1ε, CK1δ and p38 MAPK, respectively.

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TA-01 Chemical Structure
TA-01, CAS 1784751-18-3
Pack Size Availability Price/USD Quantity
1 mg In stock $ 45.00
2 mg In stock $ 64.00
5 mg In stock $ 98.00
10 mg In stock $ 178.00
25 mg In stock $ 329.00
50 mg In stock $ 547.00
100 mg In stock $ 728.00
500 mg In stock $ 1,490.00
1 mL * 10 mM (in DMSO) In stock $ 118.00
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Purity: 99.66%
Purity: 98.77%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description TA-01 is a potent CK1 and p38 MAPK inhibitor, with IC50s of 6.4 nM, 6.8 nM, 6.7 nM for CK1ε, CK1δ and p38 MAPK, respectively.
Targets&IC50 CKIδ:6.8 nM, p38 MAP kinase:6.7 nM, CKIϵ:6.4 nM 
In vitro TA-01 is a potent CK1 and p38 MAPK inhibitor, with IC50s of 6.4 nM, 6.8 nM, 6.7 nM for CK1ε, CK1δ and p38 MAPK, respectively. TA-01 (5 μM) is not cytotoxic, completely inhibits cardiogenesis, but induces cardiogenesis at lower concentration[1].
Kinase Assay Compounds (TA-01) are dissolved in DMSO?and tested at?10 μM concentrations?against a panel of 97 kinases, which are related to stem cell differentiation and cell signaling pathways. Kinome profiling is carried out by kinase profiling service[1].
Cell Research HES-3, H7 and IPS are harvested and seeded at 1.1 × 106 cells/mL as EBs in ultra-low attachment 12-well plates in bSFS medium: DMEM supplemented with 2 mM l-glutamine, 0.182 mM sodium pyruvate, 1% non-essential amino acids, 0.1 mM β-mercaptoethanol, 5.6 mg/L transferrin, 20 μg/L sodium selenite, 0.25% (w/vol) Bovine Serum Albumin and 0.25% (w/vol) Hysoy. Cells are incubated at 37°C and 5% CO2 to allow EB formation. The medium is refreshed after 1 day and then every 2-3 days. Cells are stimulated with the respective compounds (TA-01) dissolved in DMSO (1 μL DMSO/mL of media) starting from day 1 or day 4, until day 8. CHIR99021 is applied for the first 24 h only[1].
Molecular Weight 351.32
Formula C20H12F3N3
CAS No. 1784751-18-3

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 9 mg/mL (25.62 mM)

TargetMolReferences and Literature

1. Laco F, et al. Cardiomyocyte differentiation of pluripotent stem cells with SB203580 analogues correlates with Wnt pathway CK1 inhibition independent of p38 MAPK signaling. J Mol Cell Cardiol. 2015 Mar;80:56-70.

Related compound libraries

This product is contained In the following compound libraries:
Kinase Inhibitor Library Metabolism Compound Library Anti-Metabolism Disease Compound Library Cancer Cell Differentiation Compound Library Reprogramming Compound Library HIF-1 Signaling Pathway Compound Library MAPK Inhibitor Library Anti-Prostate Cancer Compound Library Anti-Pancreatic Cancer Compound Library NO PAINS Compound Library

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TAK-715 Casein kinase 1δ-IN-10 CK1-IN-3 PF-4800567 PF-670462 XL413 PF-5006739 TBCA

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Keywords

TA-01 1784751-18-3 Autophagy MAPK Metabolism Stem Cells Casein Kinase p38 MAPK TA01 Inhibitor inhibit TA 01 inhibitor

 

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