keep away from direct sunlight
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
TABERSONINE HYDROCHLORIDE is a natural product extracted from the bean of Voacanga africana, is a potent inhibitor against Aβ(1 42) aggregation and toxicity.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | In stock | $ 37.00 | |
10 mg | In stock | $ 54.00 | |
25 mg | In stock | $ 91.00 | |
50 mg | In stock | $ 137.00 | |
100 mg | In stock | $ 198.00 | |
500 mg | In stock | $ 436.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 42.00 |
Description | TABERSONINE HYDROCHLORIDE is a natural product extracted from the bean of Voacanga africana, is a potent inhibitor against Aβ(1 42) aggregation and toxicity. |
In vivo | TABERSONINE HYDROCHLORIDE is an indole alkaloid mainly isolated from Catharanthus roseus, and a potential drug candidate for treatment of cancer and Alzheimer's disease (AD), however, its anti-inflammatory effect has not been revealed.TABERSONINE HYDROCHLORIDE ameliorated lipopolysaccharides (LPS)-induced ALI in vivo and inhibited LPS-mediated macrophage activation in vitro. By using murine ALI model, we found that TABERSONINE HYDROCHLORIDE significantly attenuated LPS-induced pathological injury in the lung. TABERSONINE HYDROCHLORIDE also inhibited LPS-mediated neutrophil infiltration, elevation of MPO activity and the production of TNF-α, IL-6 and IL-1β. Furthermore, TABERSONINE HYDROCHLORIDE inhibited LPS-induced the production of pro-inflammatory mediators such as iNOS, NO and cytokines by suppressing NF-κB and p38 MAPK/MK2 signaling cascades. TABERSONINE HYDROCHLORIDE HYDROCHLORIDE reduced the K63-linked polyubiquitination of TRAF6. Taken together,TABERSONINE HYDROCHLORIDE has anti-inflammatory activities in vitro and in vivo, and is a potential therapeutic candidate for the treatment of ALI/ARDS[1]. |
Molecular Weight | 372.89 |
Formula | C21H25ClN2O2 |
CAS No. | 29479-00-3 |
keep away from direct sunlight
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 40 mg/mL (107.27 mM)
You can also refer to dose conversion for different animals. More
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TABERSONINE HYDROCHLORIDE 29479-00-3 Neuroscience Beta Amyloid Tabersonine TABERSONINE Hydrochloride inhibit Inhibitor LI/ARDS Aβ(1-42) inhibitor