Powder: -20°C for 3 years | In solvent: -80°C for 1 year
TAK-593 is an effective VEGFR and PDGFR family inhibitor (IC50s: 3.2, 0.95, 1.1, 4.3, and 13 nM for VEGFR1, VEGFR2, VEGFR3, PDFGRα, and PDFGRβ, respectively).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 44.00 | |
5 mg | In stock | $ 98.00 | |
10 mg | In stock | $ 172.00 | |
25 mg | In stock | $ 339.00 | |
50 mg | In stock | $ 525.00 | |
100 mg | In stock | $ 759.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 116.00 |
Description | TAK-593 is an effective VEGFR and PDGFR family inhibitor (IC50s: 3.2, 0.95, 1.1, 4.3, and 13 nM for VEGFR1, VEGFR2, VEGFR3, PDFGRα, and PDFGRβ, respectively). |
Targets&IC50 | PDGFRβ:13 nM, PDGFRα:4.3 nM, PDGFRαV561D:1 nM, VEGFR1:3.2 nM, VEGFR3:1.1 nM, VEGFR2:0.95 nM |
In vitro | TAK-593 inhibits the growth of HUVEC (IC50: 0.30 nM). TAK-593 also potently inhibits VEGF-induced tube formation of endothelial cells co-cultured with fibroblasts. TAK-593 potently inhibits VEGF- and PDGF-stimulated cellular phosphorylation and proliferation of human umbilical vein endothelial cells and human coronary artery smooth muscle cells. It displays effective inhibitory activity against VEGFR (VEGFR1-3: IC50=3.2, 0.95, 1.1 nM) and PDGFR (PDGFRα, β: IC50=4.3, 13 nM) families. Against other kinases, the IC50 values of TAK-593 are above 100 nM, except for Fms (IC50=10 nM) and Ret (IC50=18 nM) kinases [1][2]. |
Molecular Weight | 445.47 |
Formula | C23H23N7O3 |
CAS No. | 1005780-62-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 45 mg/mL (101.02 mM)
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
TAK-593 1005780-62-0 Angiogenesis Tyrosine Kinase/Adaptors PDGFR VEGFR TAK 593 Platelet-derived growth factor receptor Inhibitor TAK593 inhibit Vascular endothelial growth factor receptor inhibitor