Powder: -20°C for 3 years | In solvent: -80°C for 1 year
TAS0728 is a HER2 inhibitor, with antitumor activity
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 72.00 | |
5 mg | In stock | $ 189.00 | |
10 mg | In stock | $ 297.00 | |
25 mg | In stock | $ 563.00 | |
50 mg | In stock | $ 896.00 | |
100 mg | In stock | $ 1,220.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 198.00 |
Description | TAS0728 is a HER2 inhibitor, with antitumor activity |
Targets&IC50 | EGFR:65 nM , BLK:31 nM , HER2 (human):36 nM , JAK3:33 nM, BMX:4.9 nM , HER2:13 nM , HER4:8.5 nM |
In vitro | TAS0728 exhibited robust and sustained inhibition of the phosphorylation of HER2, HER3, and downstream effectors, thereby inducing apoptosis of HER2-amplified breast cancer cells and in tumor tissues of a xenograft model.?TAS0728 induced tumor regression in mouse xenograft models bearing HER2 signal-dependent tumors and exhibited a survival benefit without any evident toxicity in a peritoneal dissemination mouse model bearing HER2-driven cancer cells[1]. |
Molecular Weight | 504.58 |
Formula | C26H32N8O3 |
CAS No. | 2088323-16-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 125 mg/mL (247.73 mM)
You can also refer to dose conversion for different animals. More
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TAS0728 2088323-16-2 Angiogenesis JAK/STAT signaling Tyrosine Kinase/Adaptors EGFR HER Inhibitor TAS 0728 ErbB-1 inhibit HER1 TAS-0728 Epidermal growth factor receptor inhibitor