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TBAP-001

Catalog No. T9693 CAS 1777832-90-2

TBAP-001 is a RAF kinase inhibitor, with an IC50 of 62 nM in BRAF V600E kinase assay and an IC50 of 18 nM in Cell-Based Phosho-ERK Assay.

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TBAP-001, CAS 1777832-90-2

Pack Size	Availability	Price/USD
1 mg	In stock	$ 87.00
5 mg	In stock	$ 213.00
10 mg	In stock	$ 343.00
25 mg	In stock	$ 583.00
50 mg	In stock	$ 835.00
100 mg	In stock	$ 1,150.00
500 mg	In stock	$ 2,290.00
1 mL * 10 mM (in DMSO)	In stock	$ 248.00

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Purity: 99.3%

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Description	TBAP-001 is a RAF kinase inhibitor, with an IC50 of 62 nM in BRAF V600E kinase assay and an IC50 of 18 nM in Cell-Based Phosho-ERK Assay.
Targets&IC50	Raf:18 nM (Cell-Based Phosho-ERK Assay), Raf:62 nM (BRAF V600E kinase assay)
In vitro	The IC50 values of TBAP-001 are 178 nM (A375), 62 nM (WM266.4), 72 nM (UACC62), 93 nM (LOX INVI), 590 nM (HT 29), 43 nM (COLO225), 690 nM (RKO), 490 nM (Mawi), 390 nM (WiDr), 480 nM (Colo741), 480 nM (SW620), 600 nM (HCT116), 390 nM (SKMEL2), 710 nM (D04), 390 nM (WM1361), 1150 nM (PDAC R172H (p53 mut)), 290 nM (MiaPaCa) and 490nM (RPMI8226) in different cancer cell lines[1].

Molecular Weight	531.51
Formula	C27H23F2N7O3
CAS No.	1777832-90-2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 250 mg/mL (470.36 mM)

References and Literature

1. Caroline Joy, et al. 1 -(5-TERT-BUTYL-2-ARYL-PYRAZOL-3-YL)-3-[2-FLUORO-4-[(3-OXO-4H-PYRIDO[2, 3-B]PYRAZIN-8-YL)OXY]PHENYL]UREA DERIVATIVES AS RAF INHIBITORS FOR THE TREATMENT OF CANCER.WO2015075483A1

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Anti-Cancer Compound Library Covalent Inhibitor Library Bioactive Compound Library Anti-Ovarian Cancer Compound Library Anti-Pancreatic Cancer Compound Library Bioactive Compounds Library Max Anti-Obesity Compound Library Anti-Prostate Cancer Compound Library Anti-Liver Cancer Compound Library

Related Products

Related compounds with same targets

Effusanin A Lonafarnib ZM 336372 B-Raf IN 16 CCT241161 I-37 TAK-632 LY2452473

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

TBAP-001 1777832-90-2 MAPK Raf pancreatic TBAP001 lung Raf kinases melanoma inhibit TBAP 001 carcinoma Inhibitor colorectal inhibitor

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.