Powder: -20°C for 3 years | In solvent: -80°C for 1 year
TC-Mps1-12 is an effective and selective inhibitor of monopolar spindle 1 (IC50: 6.4 nM) .
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
10 mg | 35 days | $ 543.00 | |
50 mg | 35 days | $ 2,200.00 |
Description | TC-Mps1-12 is an effective and selective inhibitor of monopolar spindle 1 (IC50: 6.4 nM) . |
Targets&IC50 | Mps1:6.4 nM |
In vitro | TC-Mps1-12 (72 hours) inhibits the growth of cells in a dose-dependent manner (IC50: 0.84 μM). TC-Mps1-12 inhibits the growth of pMps1 cell lines (IC50: 131 nM in autophosphorylation assay) [1]. |
In vivo | TC-Mps1-12 (25-100 mg/kg; p.o.; daily; for 19 days) inhibits the growth of A549 cells in a dose-dependent manner in vivo. TC-Mps1-12 (100 mg/kg) treatment shows 47% tumor growth inhibition without body weight loss. TC-Mps1-12 (p.o., 25 mg/kg)treatment displays good PK properties with a Cmax of 3542 ng/mL and AUC of 6604 ng h/mL [1]. |
Molecular Weight | 324.38 |
Formula | C17H20N6O |
CAS No. | 1206170-62-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. More
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TC-Mps1-12 1206170-62-8 Cytoskeletal Signaling Kinesin TCMps112 TC-Mps-1-12 TC Mps1 12 inhibitor inhibit