Powder: -20°C for 3 years | In solvent: -80°C for 1 year
TCN 201 is a selective antagonist of NMDA receptors containing the NR2A subunit.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | In stock | $ 59.00 | |
10 mg | In stock | $ 98.00 | |
25 mg | In stock | $ 182.00 | |
50 mg | In stock | $ 318.00 | |
100 mg | In stock | $ 593.00 |
Description | TCN 201 is a selective antagonist of NMDA receptors containing the NR2A subunit. |
In vitro | TCN-201, a new GluN1/GluN2A-selective NMDA receptor antagonist whose inhibition can be surmounted by glycine.?Electrophysiological recordings from chimeric and mutant rat NMDA receptors suggest that TCN-201 binds to a novel allosteric site located at the dimer interface between the GluN1 and GluN2 agonist binding domains.?Occupancy of this site by TCN-201 inhibits NMDA receptor function by reducing glycine potency.?TCN-201 is therefore a negative allosteric modulator of glycine binding[1]. |
Synonyms | TCN-201 |
Molecular Weight | 461.89 |
Formula | C21H17ClFN3O4S |
CAS No. | 852918-02-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 20mg/ml(43.3mM)
You can also refer to dose conversion for different animals. More
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TCN 201 852918-02-6 Membrane transporter/Ion channel Neuroscience NMDAR iGluR GluN1 Inhibitor GluN2A inhibit TCN201 Ionotropic glutamate receptors TCN-201 inhibitor