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TH5427

Catalog No. T39785L CAS 2253744-56-6

TH5427 is a lead NUDT5 inhibitor(MG assay IC50 = 29 nM).

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

TH5427, CAS 2253744-56-6

Pack Size	Availability	Price/USD
1 mg	In stock	$ 182.00
2 mg	In stock	$ 252.00
5 mg	In stock	$ 388.00
10 mg	In stock	$ 577.00
25 mg	In stock	$ 926.00
50 mg	In stock	$ 1,260.00
100 mg	In stock	$ 1,680.00
500 mg	In stock	$ 3,380.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description	TH5427 is a lead NUDT5 inhibitor(MG assay IC50 = 29 nM).
Targets&IC50	NUDT5:29 nM(MG assay)
In vitro	In HL-60 cell lysates, TH5427(20?μM) stabilized NUDT5 to nearly the same levels as observed in the 37?°C DMSO control. TH5427 was the most potent stabilizer under the described conditions with an apparent EC50 of 2.1?μM. Accordingly, TH5427 had a positive, dose-dependent shift in the apparent Tagg—the temperature at which 50 % of the target protein denatures and aggregates (TH5427 shifted NUDT5 Tagg up to?≈?8?°C)[1].

Molecular Weight	491.33
Formula	C20H20Cl2N8O3
CAS No.	2253744-56-6

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 3.67 mg/mL (7.46 mM), Sonification is recommended

References and Literature

1. Page BDG, et al. Targeted NUDT5 inhibitors block hormone signaling in breast cancer cells [published correction appears in Nat Commun. 2019 Nov 1;10(1):5050]. Nat Commun. 2018;9(1):250.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Anti-Cancer Active Compound Library Anti-Cancer Compound Library Metabolism Compound Library Bioactive Compound Library Anti-Breast Cancer Compound Library Bioactive Compounds Library Max

Related Products

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TH1760

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

TH5427 2253744-56-6 Metabolism NUDIX hydrolase inhibit breast cancer TH 5427 proliferation Inhibitor NUDT5 ATP synthesis progestin-dependent ADP-ribose TH-5427 inhibitor

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