Powder: -20°C for 3 years | In solvent: -80°C for 1 year
TKIM is a TWIK-related potassium channel 1 (TREK-1) inhibitor, binding to the pocket of the intermediate (IM) state of TREK-1.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 96.00 | |
5 mg | In stock | $ 239.00 | |
10 mg | In stock | $ 372.00 | |
25 mg | In stock | $ 655.00 | |
50 mg | In stock | $ 918.00 | |
100 mg | In stock | $ 1,230.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 258.00 |
Description | TKIM is a TWIK-related potassium channel 1 (TREK-1) inhibitor, binding to the pocket of the intermediate (IM) state of TREK-1. |
In vitro | TKIM binds to the pocket of the IM state of TREK-1, which differs from the binding of common inhibitors, which bind to channels in the inactive state.?Overall, identified an allosteric ligand-binding site and a new mechanistic inhibitor for TREK-1, suggesting that IM states of ion channels may be promising druggable targets for use in discovering allosteric modulators. |
Molecular Weight | 371.84 |
Formula | C18H14ClN3O2S |
CAS No. | 326921-25-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 30 mg/mL (80.68 mM)
You can also refer to dose conversion for different animals. More
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TKIM 326921-25-9 Membrane transporter/Ion channel Potassium Channel inhibitor inhibit