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TUG-891

Catalog No. T3433 CAS 1374516-07-0

Synonyms: TUG 891, TUG891

TUG-891 is a G protein-coupled receptor (GPCR) expressed in intestine, adipocytes, and pro-inflammatory macrophages that is activated by long chain free fatty acids.

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TUG-891, CAS 1374516-07-0

Pack Size	Availability	Price/USD
1 mg	In stock	$ 34.00
2 mg	In stock	$ 47.00
5 mg	In stock	$ 77.00
10 mg	In stock	$ 117.00
25 mg	In stock	$ 237.00
50 mg	In stock	$ 397.00
100 mg	In stock	$ 582.00
500 mg	In stock	$ 1,230.00
1 mL * 10 mM (in DMSO)	In stock	$ 85.00

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Purity: 99.21%

Purity: 98.28%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	TUG-891 is a G protein-coupled receptor (GPCR) expressed in intestine, adipocytes, and pro-inflammatory macrophages that is activated by long chain free fatty acids.
In vitro	TUG-891 exhibits analogous signaling characteristics to the long-chain fatty acid (LCFA) α-linolenic acid at the human Free Fatty Acid receptor 4 (FFA4), stimulating Ca2+ mobilization, recruiting β-arrestin-1 and β-arrestin-2, and promoting extracellular signal-regulated kinase phosphorylation. Moreover, TUG-891 activation of FFA4 leads to the receptor's swift phosphorylation and internalization[1].
Kinase Assay	Inhibition of recombinant human Mps1 by BAY 1161909 or BAY 1217389 is assessed in TRFRET-based in vitro kinase assays via phosphorylation of a biotinylated peptide (Biotin-Ahx-PWDPDDADITEILG-NH2). Under standard assay conditions kinase and test compound are preincubated for 15 min before enzyme reaction is started by addition of substrate and ATP upon 10 μM[1].

Synonyms	TUG 891, TUG891
Molecular Weight	364.41
Formula	C23H21FO3
CAS No.	1374516-07-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 36.4 mg/mL(100 mM)

H2O: < 1 mg/mL (insoluble or slightly soluble)

References and Literature

1. Hudson BD, et al. The pharmacology of TUG-891, a potent and selective agonist of the free fatty acid receptor 4 (FFA4/GPR120), demonstrates both potential opportunity and possible challenges to therapeutic agonism. Mol Pharmacol. 2013 Nov;84(5):710-25.

Related compound libraries

This product is contained In the following compound libraries：

GPCR Compound Library Endocrinology-Hormone Compound Library Anti-Metabolism Disease Compound Library Immunology/Inflammation Compound Library Target-Focused Phenotypic Screening Library Fluorochemical Library Bioactive Compounds Library Max Anti-Obesity Compound Library Bioactive Compound Library Human Metabolite Library

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Keywords

TUG-891 1374516-07-0 Endocrinology/Hormones GPCR/G Protein GPR Inhibitor inhibit Free Fatty Acid Receptor TUG 891 TUG891 FFAR inhibitor

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