Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Tadalafil (IC-351) is a carboline-based compound with vasodilatory activity. Tadalafil selectively inhibits the cyclic guanosine monophosphate (cGMP)-specific type 5 phosphodiesterase- (PDE-5)-mediated degradation of cGMP, which is found in the smooth muscle of the corpus cavernosa and corpus spongiosum of the penis. Inhibition of cGMP degradation by tadalafil results in prolonged muscle relaxation, vasodilation, and blood engorgement of the corpus cavernosa, and, so, prolonged penile erection.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
10 mg | In stock | $ 32.00 | |
25 mg | In stock | $ 50.00 | |
50 mg | In stock | $ 73.00 | |
100 mg | In stock | $ 112.00 | |
200 mg | In stock | $ 188.00 | |
500 mg | In stock | $ 319.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 50.00 |
Description | Tadalafil (IC-351) is a carboline-based compound with vasodilatory activity. Tadalafil selectively inhibits the cyclic guanosine monophosphate (cGMP)-specific type 5 phosphodiesterase- (PDE-5)-mediated degradation of cGMP, which is found in the smooth muscle of the corpus cavernosa and corpus spongiosum of the penis. Inhibition of cGMP degradation by tadalafil results in prolonged muscle relaxation, vasodilation, and blood engorgement of the corpus cavernosa, and, so, prolonged penile erection. |
Targets&IC50 | PDE5:1.8 nM |
Synonyms | Cialis, IC-351 |
Molecular Weight | 389.4 |
Formula | C22H19N3O4 |
CAS No. | 171596-29-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 38.9 mg/mL (100 mM)
You can also refer to dose conversion for different animals. More
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Tadalafil 171596-29-5 Apoptosis Metabolism PDE IC 351 Cialis IC-351 Inhibitor inhibit IC351 Phosphodiesterase (PDE) inhibitor