Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Talmapimod hydrochloride is a selective and ATP-competitive p38α inhibitor (IC50: 9 nM). It also shows about 10-fold selectivity over p38β, and at least 2000-fold selectivity over a panel of 20 other kinases, including other MAPKs.
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25 mg | Inquiry | $ 1,520.00 |
Description | Talmapimod hydrochloride is a selective and ATP-competitive p38α inhibitor (IC50: 9 nM). It also shows about 10-fold selectivity over p38β, and at least 2000-fold selectivity over a panel of 20 other kinases, including other MAPKs. |
Targets&IC50 | p38β:90 nM, p38α:9 nM |
In vitro | Talmapimod hydrochloride inhibits LPS-induced TNF-a production in human whole blood. Talmapimod hydrochloride decreases constitutive p38alpha MAPK phosphorylation of both 5T2MM and 5T33MM cells. Talmapimod hydrochloride (100-200 nM; 1 hour) inhibits phosphorylation of p38 MAPK in MM cells [1][2][3]. |
In vivo | Talmapimod hydrochloride (10-90 mg/kg; P.o.; twice daily orally for 14 days) dose-dependently reduced tumor growth. Talmapimod hydrochloride (10-90 mg/kg; P.o.; twice daily orally for 14 days) also dose-dependently reduced weight of the palpable tumors at termination [4]. |
Synonyms | SCIO-469 hydrochloride |
Molecular Weight | 549.47 |
Formula | C27H31Cl2FN4O3 |
CAS No. | 309915-12-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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Talmapimod hydrochloride 309915-12-6 MAPK p38 MAPK SCIO 469 Hydrochloride SCIO-469 hydrochloride SCIO-469 Hydrochloride SCIO469 Hydrochloride Talmapimod Hydrochloride inhibitor inhibit