Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Taltobulin (HTI-286) is a potent tubulin inhibitor.
Description | Taltobulin (HTI-286) is a potent tubulin inhibitor. |
In vitro | HTI-286 significantly inhibited the proliferation of all three hepatic tumor cell lines (mean IC50: 2 nmol/L) in vitro. No decrease in viable primary human hepatocytes (PHH) was detected under HTI-286 exposure [1]. In all cell lines tested, HTI-286 was a potent inhibitor of proliferation and induced marked increases in apoptosis [2]. |
In vivo | Intravenous administration of HTI-286 significantly inhibited tumor growth in vivo (rat allograft model) [1]. HTI-286 significantly inhibited the growth of PC-3 and LNCaP xenografts and retained potency in PC-3dR tumors. Simultaneous castration plus HTI-286 therapy was superior to sequential treatment in the LNCaP model [2]. |
Synonyms | HTI-286, SPA-110 |
Molecular Weight | 473.65 |
Formula | C27H43N3O4 |
CAS No. | 228266-40-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 95 mg/mL (200.57 mM)
You can also refer to dose conversion for different animals. More
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Taltobulin 228266-40-8 Cytoskeletal Signaling Microtubule Associated HTI-286 HTI 286 SPA 110 SPA110 HTI286 SPA-110 inhibitor inhibit