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Tamsulosin hydrochloride

Catalog No. T0210 CAS 106463-17-6

Synonyms: Flomax, Flomax hydrochloride

Tamsulosin hydrochloride (Flomax hydrochloride) is the hydrochloride salt of tamsulosin, a sulfonamide derivative with α1 adrenergic antagonist activity.

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Tamsulosin hydrochloride Chemical Structure

Tamsulosin hydrochloride, CAS 106463-17-6

Pack Size	Availability	Price/USD
10 mg	In stock	$ 33.00
25 mg	In stock	$ 50.00
1 mL * 10 mM (in DMSO)	In stock	$ 42.00

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Purity: 100%

ee: 100%

Purity: 99.95%

Purity: 95.45%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Tamsulosin hydrochloride (Flomax hydrochloride) is the hydrochloride salt of tamsulosin, a sulfonamide derivative with α1 adrenergic antagonist activity.

In vivo

Tamsulosin exhibits high plasma-protein binding, largely to α1-acid glycoprotein. It is metabolized, mainly by cytochrome P450 (CYP) 3A4 and CYP2D6 to compounds with low abundance, and 8.7–15% of an oral dose is excreted renally as the parent compound. The pharmacokinetics of tamsulosin are not affected to a major extent by age, and pharmacokinetic alterations in renally impaired patients relate largely to an increased concentration of α1-acid glycoprotein. Pharmacokinetic alterations with hepatic impairment are also only moderate, thus neither renal nor mild to moderate hepatic impairment necessitates dose adjustment. Early studies of tamsulosin IR in experimental animals, such as rats and dogs, showed rapid absorption of tamsulosin after oral administration (within 30–90 minutes) but absolute bioavailability of only 7–23% in rats and 30–42% in dogs. The absolute bioavailability of tamsulosin MR in fasted humans is approximately 100%. The tmax is typically about 5 hours (reported range of mean values 2.9-5.6 hours) in the fasted state and about 6 hours in the fed state (range 5.2-7.0 hours). Animal studies involving intravenous injection of radiolabelled tamsulosin and measurement of radiolabel in various tissues after 10 minutes have shown the presence of the drug in various tissues, ranked in the following order: kidney>lung≈heart>submaxillary gland>liver ≈spleen≈aorta≈vas deferens> prostate>>cerebral cortex, the latter being close to detection limits. Tamsulosin may not pass the blood-brain barrier.

Synonyms	Flomax, Flomax hydrochloride
Molecular Weight	444.97
Formula	C20H29ClN2O5S
CAS No.	106463-17-6

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 44.5 mg/mL (100 mM)

H2O: 4.5 mg/mL (10 mM)

References and Literature

1. Franco-Salinas G, et al. Clin Pharmacokinet. 2010, 49(3):177-88. 2. Kuo GH, et al. Bioorg Med Chem. 2000, 8(9):2263-75. 3. Okutsu H, et al. Urology. 2010, 75(1):235-40.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library GPCR Compound Library Anti-Cancer Drug Library Anti-Cancer Approved Drug Library Drug Repurposing Compound Library Anti-Neurodegenerative Disease Compound Library Membrane Protein-targeted Compound Library Anti-Cancer Clinical Compound Library Bioactive Compounds Library Max Coagulation and Anticoagulation Compound Library

Related Products

Related compounds with same targets

RS 17053 hydrochloride BMY 7378 dihydrochloride Mibenratide TFA Cisatracurium besylate Doxazosin mesylate Formoterol fumarate Labetalol hydrochloride Buflomedil hydrochloride

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Tamsulosin hydrochloride 106463-17-6 GPCR/G Protein Neuroscience Adrenergic Receptor Flomax LY 253351 Flomax hydrochloride LY-253351 Inhibitor LY253351 Beta Receptor inhibit Tamsulosin Flomax Hydrochloride Tamsulosin Hydrochloride inhibitor

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