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Tarenflurbil

Catalog No. T5843   CAS 51543-40-9
Synonyms: MPC7869, (R)-Flurbiprofen, R-flurbiprofen

Tarenflurbil ((R)-Flurbiprofen) is the non-cyclooxygenase inhibiting R-enantiomer of the non-steroidal anti-inflammatory drug flurbiprofen, which was assessed as a remedy for Alzheimer's disease.

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Tarenflurbil Chemical Structure
Tarenflurbil, CAS 51543-40-9
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Purity: 98%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Tarenflurbil ((R)-Flurbiprofen) is the non-cyclooxygenase inhibiting R-enantiomer of the non-steroidal anti-inflammatory drug flurbiprofen, which was assessed as a remedy for Alzheimer's disease.
Targets&IC50 RXRα:75 μM
In vivo Oral R-flurbiprofen prevented and attenuated primary progressive EAE in C57BL6/J mice and relapsing-remitting EAE in SJL mice, even if the treatment was initiated on or after the first flare of the disease.?R-flurbiprofen reduced immune cell infiltration and microglia activation and inflammation in the spinal cord, brain and optic nerve and attenuated myelin destruction and EAE-evoked hyperalgesia.?R-flurbiprofen treatment increased CD4(+)CD25(+)FoxP3(+) regulatory T cells, CTLA4(+) inhibitory T cells and interleukin-10, whereas the EAE-evoked upregulation of pro-inflammatory genes in the spinal cord was strongly reduced.?The effects were associated with an increase of plasma and cortical endocannabinoids but decreased spinal prostaglandins, the latter likely due to R to S inversion.
Animal Research Bone marrow transplantation (BMX), recipient C57BL6/J mice received a 9.5 Gy cobalt 60 gamma irradiation and subsequently an intravenous injection through the tail vein of 6 × 10^6 bone marrow cells, which were harvested from tibia and femur of β-actin-EGFP donor mice.?Immunization was done with MOG35-55/CFA emulsion plus PTX 3 weeks after BMX and treatment with R-flurbiprofen or vehicle started 3 days after immunization.
Synonyms MPC7869, (R)-Flurbiprofen, R-flurbiprofen
Molecular Weight 244.26
Formula C15H13FO2
CAS No. 51543-40-9

Storage

store at low temperature

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 50 mg/mL (204.70 mM)

TargetMolReferences and Literature

1. Schmitz K , De Bruin N , Bishay P , et al. R-flurbiprofen attenuates experimental autoimmune encephalomyelitis in mice[J]. EMBO Molecular Medicine, 2014, 6(11):1398-1422.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Neurodegenerative Disease Compound Library Nuclear Receptor Compound Library Neuronal Differentiation Compound Library Anti-Metabolism Disease Compound Library Metabolism Compound Library NO PAINS Compound Library Autophagy Compound Library Anti-Fibrosis Compound Library Nonsteroidal Anti-Inflammatory Compound Library Bioactive Lipid Compound Library

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Keywords

Tarenflurbil 51543-40-9 Autophagy Metabolism Retinoid Receptor MPC7869 Retinoic acid receptors Flurbiprofen (R)-Flurbiprofen Retinoid X receptors R-flurbiprofen Inhibitor MPC 7869 RAR/RXR inhibit MPC-7869 inhibitor

 

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