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Telmisartan

Catalog No. T1570   CAS 144701-48-4
Synonyms: BIBR 277

Telmisartan (BIBR 277) is an Angiotensin 2 Receptor Blocker. The mechanism of action of telmisartan is as an Angiotensin 2 Receptor Antagonist.

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Telmisartan Chemical Structure
Telmisartan, CAS 144701-48-4
Pack Size Availability Price/USD Quantity
25 mg In stock $ 41.00
50 mg In stock $ 58.00
100 mg In stock $ 90.00
200 mg In stock $ 112.00
500 mg In stock $ 148.00
1 g In stock $ 234.00
1 mL * 10 mM (in DMSO) In stock $ 50.00
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Purity: 99.96%
Purity: 98.78%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Telmisartan (BIBR 277) is an Angiotensin 2 Receptor Blocker. The mechanism of action of telmisartan is as an Angiotensin 2 Receptor Antagonist.
Targets&IC50 angiotensin II type 1 receptor (AT1):9.2 nM
Cell Research Telmisartan is prepared as a 10 mM stock solution in DMSO. Cell proliferation is assayed using the CCK-8 cell counting kit. Briefly, 5×103 cells are seeded into each well of a 96-well plate and cultured in 100 μL of RPMI-1640 supplemented with 10% FBS. After 24 h, ARBs (telmisartan, irbesartan, losartan, and valsartan at 0, 1, 10, or 100 μM) or vehicle is added to each well, and cells are cultured for an additional 48 h. CCK-8 reagent (10 μL) is added to each well, and the plates are incubated at 37°C for 3 h. The absorbance is measured at 450 nm using a microplate reader.
Synonyms BIBR 277
Molecular Weight 514.62
Formula C33H30N4O2
CAS No. 144701-48-4

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 10.3 mg/mL (20 mM)

TargetMolReferences and Literature

1. Benson SC, et al. Hypertension, 2004, 43(5), 993-1002. 2. Yoshida T, et al. Diabetologia, 2006, 49(12), 3094-3099. 3. Fujimoto M, et al. FEBS Lett, 2004, 576(3), 492-497. 4. Sugimoto K et al. Hypertension, 2006, 47(5), 12003-12009. 6. Torika N, et al. Intranasal telmisartan ameliorates brain pathology in five familial Alzheimer's disease mice. Brain Behav Immun. 2017 Apr 3. 7. Aswar U, et al. Telmisartan attenuates diabetes induced depression in rats. Pharmacol Rep. 2017 Apr;69(2):358-364. 8. Fujihara S, et al. The angiotensin II type 1 receptor antagonist telmisartan inhibits cell proliferation and tumor growth of esophageal adenocarcinoma via the AMPKα/mTOR pathway in vitro and in vivo. Oncotarget. 2017 Jan 31;8(5):8536-8549.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Cancer Drug Library Anti-Cancer Approved Drug Library Anti-Cancer Clinical Compound Library Orally Active Compound Library NO PAINS Compound Library Angiogenesis related Compound Library Anti-COVID-19 Compound Library Endocrinology-Hormone Compound Library Bioactive Compounds Library Max FDA-Approved & Pharmacopeia Drug Library

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Keywords

Telmisartan 144701-48-4 Autophagy Endocrinology/Hormones RAAS BIBR 277 Angiotensin Receptor inhibit Inhibitor BIBR277 BIBR-277 inhibitor

 

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