Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Telotristat ethyl (LX1606) is a orally-delivered inhibitor of tryptophan hydroxylase that reduces serotonin production.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 41.00 | |
2 mg | In stock | $ 59.00 | |
5 mg | In stock | $ 97.00 | |
10 mg | In stock | $ 179.00 | |
25 mg | In stock | $ 298.00 | |
50 mg | In stock | $ 443.00 | |
100 mg | In stock | $ 653.00 | |
500 mg | In stock | $ 1,390.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 123.00 |
Description | Telotristat ethyl (LX1606) is a orally-delivered inhibitor of tryptophan hydroxylase that reduces serotonin production. |
In vivo | Telotristat ethyl (200 mg/kg po, qd) protects the mouse IBD model confirmed by histopathology evaluation[1]. Telotristat ethyl (15, 50, 150, 300 mg/kg) depletes 5-HT from the jejunum but not the brain. However, Telotristat ethyl (200 mg/kg, p.o.) does not deplete enteric neuronal serotonin (5-HT) nor alter constitutive gastrointestinal motility in mice. Telotristat ethyl (200 mg/kg) alleviates the severity of trinitrobenzene sulfonic acid (TNBS)-induced colitis[2]. Telotristat ethyl (15, 50, 150, 300 mg/kg, po, qd) reduces serotonin content in the periphery but not in the brain of the mice. Telotristat ethyl (200 mg/kg po, qd) prevents the increase in blood neutrophil counts that is observed after TNBS challenge, provides significant protection in a mouse model of inflammatory bowel disease. |
Synonyms | LX1606 |
Molecular Weight | 574.98 |
Formula | C27H26ClF3N6O3 |
CAS No. | 1033805-22-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 98.5 mg/mL (171.31mM)
You can also refer to dose conversion for different animals. More
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Telotristat ethyl 1033805-22-9 Metabolism Hydroxylase inhibit LX-1606 LX1606 LX 1032 Inhibitor LX-1032 Tryptophan Hydroxylase LX 1606 LX1032 inhibitor