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Telotristat ethyl

Catalog No. T11897   CAS 1033805-22-9
Synonyms: LX1606

Telotristat ethyl (LX1606) is a orally-delivered inhibitor of tryptophan hydroxylase that reduces serotonin production.

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Telotristat ethyl Chemical Structure
Telotristat ethyl, CAS 1033805-22-9
Pack Size Availability Price/USD Quantity
1 mg In stock $ 41.00
2 mg In stock $ 59.00
5 mg In stock $ 97.00
10 mg In stock $ 179.00
25 mg In stock $ 298.00
50 mg In stock $ 443.00
100 mg In stock $ 653.00
500 mg In stock $ 1,390.00
1 mL * 10 mM (in DMSO) In stock $ 123.00
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Purity: 99.72%
Purity: 98.11%
Purity: 98%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Telotristat ethyl (LX1606) is a orally-delivered inhibitor of tryptophan hydroxylase that reduces serotonin production.
In vivo Telotristat ethyl (200 mg/kg po, qd) protects the mouse IBD model confirmed by histopathology evaluation[1]. Telotristat ethyl (15, 50, 150, 300 mg/kg) depletes 5-HT from the jejunum but not the brain. However, Telotristat ethyl (200 mg/kg, p.o.) does not deplete enteric neuronal serotonin (5-HT) nor alter constitutive gastrointestinal motility in mice. Telotristat ethyl (200 mg/kg) alleviates the severity of trinitrobenzene sulfonic acid (TNBS)-induced colitis[2]. Telotristat ethyl (15, 50, 150, 300 mg/kg, po, qd) reduces serotonin content in the periphery but not in the brain of the mice. Telotristat ethyl (200 mg/kg po, qd) prevents the increase in blood neutrophil counts that is observed after TNBS challenge, provides significant protection in a mouse model of inflammatory bowel disease.
Synonyms LX1606
Molecular Weight 574.98
Formula C27H26ClF3N6O3
CAS No. 1033805-22-9

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 98.5 mg/mL (171.31mM)

TargetMolReferences and Literature

1. Tamas Oravecz, et al. LX1606 (aka LX1032), a Novel Inhibitor of Serotonin Synthesis, Alleviates Development of Inflammatory Bowel Disease in a Preclinical Model. 2. Margolis, K.G., et al., Pharmacological reduction of mucosal but not neuronal serotonin opposes inflammation in mouse intestine. Gut, 2013.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Cancer Active Compound Library Anti-Cancer Drug Library Anti-Cancer Clinical Compound Library Anti-Cancer Approved Drug Library Anti-Metabolism Disease Compound Library Drug Repurposing Compound Library Bioactive Compound Library Drug-induced Liver Injury (DILI) Compound Library ReFRAME Related Library Bioactive Compounds Library Max

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EWP 815 Fenclonine Rodatristat ethyl Osilodrostat GSK180 LX-1031 Sapropterin dihydrochloride LPA2 antagonist 1

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Keywords

Telotristat ethyl 1033805-22-9 Metabolism Hydroxylase inhibit LX-1606 LX1606 LX 1032 Inhibitor LX-1032 Tryptophan Hydroxylase LX 1606 LX1032 inhibitor

 

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