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Tenovin-6 Hydrochloride

Catalog No. T8480   CAS 1011301-29-3

Tenovin-6 Hydrochloride is an SIRT1, SIRT2 and HDAC8 inhibitor(IC50s of 21 μM, 10 μM, and 67 μM for SirT1, SirT2, and SirT3, respectively), and is also a potent p53 activator .

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Tenovin-6 Hydrochloride Chemical Structure
Tenovin-6 Hydrochloride, CAS 1011301-29-3
Pack Size Availability Price/USD Quantity
1 mg In stock $ 33.00
2 mg In stock $ 47.00
5 mg In stock $ 64.00
10 mg In stock $ 80.00
25 mg In stock $ 143.00
50 mg In stock $ 238.00
100 mg In stock $ 396.00
1 mL * 10 mM (in DMSO) In stock $ 67.00
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Purity: 100%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Tenovin-6 Hydrochloride is an SIRT1, SIRT2 and HDAC8 inhibitor(IC50s of 21 μM, 10 μM, and 67 μM for SirT1, SirT2, and SirT3, respectively), and is also a potent p53 activator .
Targets&IC50 SIRT1:21 μM, SIRT3:67 μM, SIRT2:10 μM
In vitro Inhibition of SIRT1/2 by Tenovin-6 induced apoptosis in UM cells by activating the expression of tumor suppressor genes such as p53 and elevating reactive oxygen species (ROS).?Tenovin-6 inhibited the growth of UM cells.?Tenovin-6 and vinblastine was synergistic in inducing apoptosis of UM cell line 92.1 and Mel 270.?Furthermore, Tenovin-6 eliminated cancer stem cells in 92.1 and Mel 270 cells.?In conclusion, our findings suggest that Tenovin-6 may be a promising agent to kill UM bulk tumor cells and CSCs[1].tenovin-6 increases microtubule-associated protein 1 light chain 3 (LC3-II) level in diverse cell types in a time- and dose-dependent manner. Mechanistically, the increase of LC3-II by tenovin-6 is caused by inhibition of the classical autophagy pathway via impairing lysosomal function without affecting the fusion between autophagosomes and lysosomes.tenovin-6 activation of p53 is cell type dependent, and tenovin-6 inhibition of autophagy is not dependent on its regulatory functions on p53 and SIRT1[2].
Molecular Weight 491.09
Formula C25H35ClN4O2S
CAS No. 1011301-29-3

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 45 mg/mL (91.63 mM)

TargetMolReferences and Literature

1. Dai W, et al. Class III-specific HDAC inhibitor Tenovin-6 induces apoptosis, suppresses migration and eliminates cancer stem cells in uveal melanoma. Sci Rep. 2016 Mar 4;6:22622. 2. Yuan H, et al. Tenovin-6 impairs autophagy by inhibiting autophagic flux. Cell Death Dis. 2017 Feb 9;8(2):e2608.

Related compound libraries

This product is contained In the following compound libraries:
Bioactive Compounds Library Max Anti-Aging Compound Library Stem Cell Differentiation Compound Library Transcription Factor-Targeted Compound Library Pyroptosis Compound Library Anti-Breast Cancer Compound Library Anti-Lung Cancer Compound Library Ubiquitination Compound Library Glutamine Metabolism Compound Library NO PAINS Compound Library

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Keywords

Tenovin-6 Hydrochloride 1011301-29-3 Apoptosis Autophagy Chromatin/Epigenetic DNA Damage/DNA Repair Metabolism Dehydrogenase Sirtuin HDAC p53 acetylation Dihydroorotate Dehydrogenase protein-deacetylating Tenovin 6 Hydrochloride DHODH Tenovin 6 Inhibitor degradation Tenovin6 Tenovin6 Hydrochloride inhibit MDM2 MDM-2/p53 Tenovin-6 inhibitor

 

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