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Theaflavin 3,3'-digallate

Catalog No. T5429   CAS 30462-35-2
Synonyms: 8-Gingerol, TFDG

Theaflavin 3,3'-digallate (8-Gingerol) , a major polyphenol found in black tea, is an inducer of oxidative stress which has anti-inflammatory and cancer chemopreventive actions, it reduces tumor angiogenesis by downregulating HIF-1αand VEGF.

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Theaflavin 3,3'-digallate Chemical Structure
Theaflavin 3,3'-digallate, CAS 30462-35-2
Pack Size Availability Price/USD Quantity
1 mg In stock $ 84.00
5 mg In stock $ 182.00
10 mg In stock $ 297.00
25 mg In stock $ 525.00
50 mg In stock $ 748.00
100 mg In stock $ 987.00
1 mL * 10 mM (in DMSO) In stock $ 297.00
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Purity: 99.86%
Purity: 98.93%
Purity: 98.71%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Theaflavin 3,3'-digallate (8-Gingerol) , a major polyphenol found in black tea, is an inducer of oxidative stress which has anti-inflammatory and cancer chemopreventive actions, it reduces tumor angiogenesis by downregulating HIF-1αand VEGF.
In vitro 8-Gingerol has antioxidant activity, inhibiting the formation of superoxide radicals, singlet oxygen, hydrogen peroxide, and hydroxyl radicals in vitro (IC50s = 26.7, 0.83, 0.39, and 25.07 μmol/L, respectively) [1].
In vivo In vivo, 8-Gingerol reduces serum levels of TNF-α, IL-1β, and IL-6 and decreases pulmonary edema, pulmonary congestion, and thickening of the alveolar wall in a mouse model of LPS-induced acute lung injury. It also inhibits osteoclast formation, polarization, and osteoclastic bone resorption in vitro and reduces titanium particle-induced bone erosion and the number of mature osteoclasts in mice in a dose-dependent manner [3].
Synonyms 8-Gingerol, TFDG
Molecular Weight 868.7
Formula C43H32O20
CAS No. 30462-35-2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 10 mg/mL (11.51 mM)

Ethanol: 10 mg/mL

TargetMolReferences and Literature

1. Wu YY, et al. Evaluation of the antioxidant effects of four main theaflavin derivatives through chemiluminescence and DNA damage analyses. J Zhejiang Univ Sci B. 2011 Sep;12(9):744-51. 2. Tanaka T, et al. Increase of theaflavin gallates and thearubigins by acceleration of catechin oxidation in a new fermented tea product obtained by the tea-rolling processing of loquat ( Eriobotrya japonica ) and green tea leaves. J Agric Food Chem. 2009 Jul 8;57(13):5816-22. 3. Hu X, et al. Theaflavin-3,3'-digallate represses osteoclastogenesis and prevents wear debris-induced osteolysis via suppression of ERK pathway. Acta Biomater. 2017 Jan 15;48:479-488.

TargetMolCitations

1. Zhang H, Liang B, Sang X, et al.Discovery of Potential Inhibitors of SARS-CoV-2 Main Protease by a Transfer Learning Method.Viruses.2023, 15(4): 891.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Cancer Clinical Compound Library Anti-Cancer Active Compound Library Anti-Cancer Drug Library Oxidation-Reduction Compound Library Anti-Infection Compound Library Inhibitor Library Selected Plant-Sourced Compound Library Antioxidant Compound Library Human Metabolite Library Protease Inhibitor Library

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Keywords

Theaflavin 3,3'-digallate 30462-35-2 Microbiology/Virology oxidation-reduction Proteases/Proteasome HSV HIV Protease Virus Protease Antioxidant TF 3 TF3 ZIKV Theaflavin 3,3' digallate ZP10 HIV Human immunodeficiency virus replication ERK1/2 p53 p21 Akt U87 ZP 10 MAPK translation gp41 8-Gingerol Inhibitor NF-κB Theaflavin 3,3'digallate NS3 Herpes simplex virus TFDG NS2B-3 inhibit ZP-10 TF-3 inhibitor

 

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