Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Theaflavin 3,3'-digallate (8-Gingerol) , a major polyphenol found in black tea, is an inducer of oxidative stress which has anti-inflammatory and cancer chemopreventive actions, it reduces tumor angiogenesis by downregulating HIF-1αand VEGF.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 84.00 | |
5 mg | In stock | $ 182.00 | |
10 mg | In stock | $ 297.00 | |
25 mg | In stock | $ 525.00 | |
50 mg | In stock | $ 748.00 | |
100 mg | In stock | $ 987.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 297.00 |
Description | Theaflavin 3,3'-digallate (8-Gingerol) , a major polyphenol found in black tea, is an inducer of oxidative stress which has anti-inflammatory and cancer chemopreventive actions, it reduces tumor angiogenesis by downregulating HIF-1αand VEGF. |
In vitro | 8-Gingerol has antioxidant activity, inhibiting the formation of superoxide radicals, singlet oxygen, hydrogen peroxide, and hydroxyl radicals in vitro (IC50s = 26.7, 0.83, 0.39, and 25.07 μmol/L, respectively) [1]. |
In vivo | In vivo, 8-Gingerol reduces serum levels of TNF-α, IL-1β, and IL-6 and decreases pulmonary edema, pulmonary congestion, and thickening of the alveolar wall in a mouse model of LPS-induced acute lung injury. It also inhibits osteoclast formation, polarization, and osteoclastic bone resorption in vitro and reduces titanium particle-induced bone erosion and the number of mature osteoclasts in mice in a dose-dependent manner [3]. |
Synonyms | 8-Gingerol, TFDG |
Molecular Weight | 868.7 |
Formula | C43H32O20 |
CAS No. | 30462-35-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 10 mg/mL (11.51 mM)
Ethanol: 10 mg/mL
You can also refer to dose conversion for different animals. More
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Theaflavin 3,3'-digallate 30462-35-2 Microbiology/Virology oxidation-reduction Proteases/Proteasome HSV HIV Protease Virus Protease Antioxidant TF 3 TF3 ZIKV Theaflavin 3,3' digallate ZP10 HIV Human immunodeficiency virus replication ERK1/2 p53 p21 Akt U87 ZP 10 MAPK translation gp41 8-Gingerol Inhibitor NF-κB Theaflavin 3,3'digallate NS3 Herpes simplex virus TFDG NS2B-3 inhibit ZP-10 TF-3 inhibitor